Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. (Gene Ontology, GO_0035664)
1 genes participating in the tirap-dependent toll-like receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.