tlr2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description toll-like receptor 2|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7097)
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Genes

175 genes co-occuring with the biological term tlr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AIF1 allograft inflammatory factor 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOH apolipoprotein H (beta-2-glycoprotein I)
ARRB2 arrestin, beta 2
BGN biglycan
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
CAMP cathelicidin antimicrobial peptide
CAPN1 calpain 1, (mu/I) large subunit
CCL13 chemokine (C-C motif) ligand 13
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD200 CD200 molecule
CD209 CD209 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CLEC4M C-type lectin domain family 4, member M
CLEC7A C-type lectin domain family 7, member A
CNPY4 canopy FGF signaling regulator 4
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CSF3 colony stimulating factor 3 (granulocyte)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB103B defensin, beta 103B
DEFB4A defensin, beta 4A
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASLG Fas ligand (TNF superfamily, member 6)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF10 fibroblast growth factor 10
GPATCH1 G patch domain containing 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB1 high mobility group box 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL16 interleukin 16
IL17A interleukin 17A
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL31 interleukin 31
IL6 interleukin 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF3 interferon regulatory factor 3
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JCHAIN joining chain of multimeric IgA and IgM
LBP lipopolysaccharide binding protein
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAL mal, T-cell differentiation protein
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MBL2 mannose-binding lectin (protein C) 2, soluble
MIR1225 microRNA 1225
MIR132 microRNA 132
MIR143 microRNA 143
MIR146A microRNA 146a
MIR1915 microRNA 1915
MIR19A microRNA 19a
MIR212 microRNA 212
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCR2 natural cytotoxicity triggering receptor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP2 NLR family, pyrin domain containing 2
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
PAX2 paired box 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PROKR2 prokineticin receptor 2
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAA1 serum amyloid A1
SFTPA1 surfactant protein A1
SFTPD surfactant protein D
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNAPIN SNAP-associated protein
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEK TEK tyrosine kinase, endothelial
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREM1 triggering receptor expressed on myeloid cells 1
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTN vitronectin
WNT5A wingless-type MMTV integration site family, member 5A
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZG16B zymogen granule protein 16B