tlr3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description toll-like receptor 3|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7098)
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Genes

121 genes co-occuring with the biological term tlr3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM15 ADAM metallopeptidase domain 15
AKT1 v-akt murine thymoma viral oncogene homolog 1
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD209 CD209 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD86 CD86 molecule
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CSK c-src tyrosine kinase
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ELMOD2 ELMO/CED-12 domain containing 2
FLT1 fms-related tyrosine kinase 1
FPR2 formyl peptide receptor 2
GPR15 G protein-coupled receptor 15
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNA2 interferon, alpha 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12A interleukin 12A
IL18 interleukin 18
IL1B interleukin 1, beta
IL27 interleukin 27
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRF3 interferon regulatory factor 3
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
KIAA0368 KIAA0368
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT12 keratin 12, type I
LGALS9 lectin, galactoside-binding, soluble, 9
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MGA MGA, MAX dimerization protein
MIR148B microRNA 148b
MIR152 microRNA 152
MIR29B1 microRNA 29b-1
MIR29C microRNA 29c
MIR758 microRNA 758
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
PFN1 profilin 1
PIGR polymeric immunoglobulin receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PRAME preferentially expressed antigen in melanoma
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFTN1 raftlin, lipid raft linker 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RSAD2 radical S-adenosyl methionine domain containing 2
RXRA retinoid X receptor, alpha
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SORBS2 sorbin and SH3 domain containing 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBK1 TANK-binding kinase 1
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP63 tumor protein p63
TRIL TLR4 interactor with leucine-rich repeats
TRIM21 tripartite motif containing 21
TRIM23 tripartite motif containing 23
TRIM5 tripartite motif containing 5
TRIM56 tripartite motif containing 56
TSLP thymic stromal lymphopoietin
UNC93B1 unc-93 homolog B1 (C. elegans)
WNT5A wingless-type MMTV integration site family, member 5A