tlr4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description toll-like receptor 4|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 7099)
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Genes

244 genes co-occuring with the biological term tlr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ACE angiotensin I converting enzyme
ACKR3 atypical chemokine receptor 3
ADAM15 ADAM metallopeptidase domain 15
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CC2D1A coiled-coil and C2 domain containing 1A
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR8 chemokine (C-C motif) receptor 8
CD14 CD14 molecule
CD180 CD180 molecule
CD19 CD19 molecule
CD1B CD1b molecule
CD200 CD200 molecule
CD209 CD209 molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELA3B chymotrypsin-like elastase family, member 3B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHUK conserved helix-loop-helix ubiquitous kinase
CLEC7A C-type lectin domain family 7, member A
CNPY4 canopy FGF signaling regulator 4
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CTAG1B cancer/testis antigen 1B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DUOX2 dual oxidase 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCAMR Fc receptor, IgA, IgM, high affinity
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF10 fibroblast growth factor 10
FN1 fibronectin 1
FOXP3 forkhead box P3
FSTL1 follistatin-like 1
GMFG glia maturation factor, gamma
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPATCH1 G patch domain containing 1
HAVCR2 hepatitis A virus cellular receptor 2
HDAC2 histone deacetylase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HRH1 histamine receptor H1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AA2P heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL23R interleukin 23 receptor
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRGM immunity-related GTPase family, M
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA1804 mixed lineage kinase 4
LBP lipopolysaccharide binding protein
LRP1 low density lipoprotein receptor-related protein 1
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAL mal, T-cell differentiation protein
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR146A microRNA 146a
MIR146B microRNA 146b
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR203A microRNA 203a
MIRLET7A1 microRNA let-7a-1
MIRLET7B microRNA let-7b
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYD88 myeloid differentiation primary response 88
NEU1 sialidase 1 (lysosomal sialidase)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOX4 NADPH oxidase 4
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDCD1 programmed cell death 1
PIGR polymeric immunoglobulin receptor
PLA1A phospholipase A1 member A
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB11A RAB11A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100A4 S100 calcium binding protein A4
S100A7A S100 calcium binding protein A7A
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAA1 serum amyloid A1
SDCBP syndecan binding protein (syntenin)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SFTPD surfactant protein D
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRT1 sirtuin 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYK spleen tyrosine kinase
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIPE2 TNF alpha induced protein 8 like 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TMED7 transmembrane emp24 protein transport domain containing 7
TNC tenascin C
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIL TLR4 interactor with leucine-rich repeats
TRIM21 tripartite motif containing 21
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF160 zinc finger protein 160