tlr7 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description toll-like receptor 7|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 51284)
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Genes

42 genes co-occuring with the biological term tlr7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BTK Bruton agammaglobulinemia tyrosine kinase
CD14 CD14 molecule
CD300A CD300a molecule
CD300C CD300c molecule
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL10 interleukin 10
IL23A interleukin 23, alpha subunit p19
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LTF lactotransferrin
MARCH5 membrane-associated ring finger (C3HC4) 5
MIR3148 microRNA 3148
MIR758 microRNA 758
MIRLET7B microRNA let-7b
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
TANK TRAF family member-associated NFKB activator
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRIM21 tripartite motif containing 21
TSHR thyroid stimulating hormone receptor
UNC93B1 unc-93 homolog B1 (C. elegans)