tlr9 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description toll-like receptor 9|The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 54106)
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Genes

76 genes co-occuring with the biological term tlr9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARF6 ADP-ribosylation factor 6
BCR breakpoint cluster region
BTK Bruton agammaglobulinemia tyrosine kinase
CD14 CD14 molecule
CD180 CD180 molecule
CD300A CD300a molecule
CD300C CD300c molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
ESR1 estrogen receptor 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FOXN3 forkhead box N3
FOXP3 forkhead box P3
HMGB1 high mobility group box 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDO1 indoleamine 2,3-dioxygenase 1
IFIH1 interferon induced with helicase C domain 1
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL21 interleukin 21
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IRF7 interferon regulatory factor 7
LDLR low density lipoprotein receptor
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MIR574 microRNA 574
MIR7-1 microRNA 7-1
MIR7-2 microRNA 7-2
MIR7-3 microRNA 7-3
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFA transforming growth factor, alpha
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRIM21 tripartite motif containing 21
TSLP thymic stromal lymphopoietin
UNC93B1 unc-93 homolog B1 (C. elegans)