tnf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description tumor necrosis factor|This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7124)
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Genes

280 genes co-occuring with the biological term tnf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLN apelin
APOA1 apolipoprotein A-I
APOE apolipoprotein E
ARF6 ADP-ribosylation factor 6
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BDNF brain-derived neurotrophic factor
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTK Bruton agammaglobulinemia tyrosine kinase
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD8A CD8a molecule
CDK9 cyclin-dependent kinase 9
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHGA chromogranin A
CHUK conserved helix-loop-helix ubiquitous kinase
CLOCK clock circadian regulator
CNR2 cannabinoid receptor 2 (macrophage)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DUSP14 dual specificity phosphatase 14
EDA ectodysplasin A
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ENG endoglin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHB2 EPH receptor B2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F10 coagulation factor X
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXO1 forkhead box O1
FOXP3 forkhead box P3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GDF15 growth differentiation factor 15
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOLGA4 golgin A4
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
HBEGF heparin-binding EGF-like growth factor
HCK HCK proto-oncogene, Src family tyrosine kinase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HP haptoglobin
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFN1@ interferon, type 1, cluster
IFNA10 interferon, alpha 10
IFNA17 interferon, alpha 17
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL11 interleukin 11
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL16 interleukin 16
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL24 interleukin 24
IL3 interleukin 3
IL32 interleukin 32
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IPO8 importin 8
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAG1 jagged 1
JUN jun proto-oncogene
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KL klotho
KPNB1 karyopherin (importin) beta 1
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIMK1 LIM domain kinase 1
LOX lysyl oxidase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR125B1 microRNA 125b-1
MIR125B2 microRNA 125b-2
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MYD88 myeloid differentiation primary response 88
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NKAP NFKB activating protein
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
OLFM4 olfactomedin 4
OPRM1 opioid receptor, mu 1
OTULIN OTU deubiquitinase with linear linkage specificity
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PGR progesterone receptor
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHO1 pleckstrin homology domain containing, family O member 1
POU2F1 POU class 2 homeobox 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCZ protein kinase C, zeta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RELL1 RELT-like 1
RELL2 RELT-like 2
RETN resistin
RFK riboflavin kinase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF216 ring finger protein 216
RNF31 ring finger protein 31
S100A12 S100 calcium binding protein A12
SCAP SREBF chaperone
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SH3KBP1 SH3-domain kinase binding protein 1
SIRT4 sirtuin 4
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SPHK1 sphingosine kinase 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSB Sjogren syndrome antigen B (autoantigen La)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TFG TRK-fused gene
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIP3 TNFAIP3 interacting protein 3
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TRIM8 tripartite motif containing 8
USP2 ubiquitin specific peptidase 2
VCAM1 vascular cell adhesion molecule 1
WNT2B wingless-type MMTV integration site family, member 2B
WNT9B wingless-type MMTV integration site family, member 9B
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO1 exportin 1
XPO7 exportin 7