tnf Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description tumor necrosis factor|This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7124)
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Genes

61 proteins co-occuring with the biological term tnf in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF1 activating transcription factor 1
BMX BMX non-receptor tyrosine kinase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
CREB1 cAMP responsive element binding protein 1
CYLD cylindromatosis (turban tumor syndrome)
DAB2IP DAB2 interacting protein
EGFR epidermal growth factor receptor
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
GLO1 glyoxalase I
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IP6K2 inositol hexakisphosphate kinase 2
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KDR kinase insert domain receptor
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIAS1 protein inhibitor of activated STAT, 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKD1 protein kinase D1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS10 regulator of G-protein signaling 10
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
THEMIS2 thymocyte selection associated family member 2
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
WWOX WW domain containing oxidoreductase
ZFP36 ZFP36 ring finger protein