tobramycin-4162 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tobramycin-4162 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABI2 abl-interactor 2
ACTC1 actin, alpha, cardiac muscle 1
ADAM23 ADAM metallopeptidase domain 23
ADAM8 ADAM metallopeptidase domain 8
ADRB3 adrenoceptor beta 3
AFF1 AF4/FMR2 family, member 1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APAF1 apoptotic peptidase activating factor 1
APOL3 apolipoprotein L, 3
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C14ORF1 chromosome 14 open reading frame 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CARD10 caspase recruitment domain family, member 10
CD14 CD14 molecule
CD1E CD1e molecule
CD247 CD247 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD7 CD7 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC14B cell division cycle 14B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFAP69 cilia and flagella associated protein 69
CIB2 calcium and integrin binding family member 2
CLTA clathrin, light chain A
COL1A1 collagen, type I, alpha 1
CRISP2 cysteine-rich secretory protein 2
CROCC ciliary rootlet coiled-coil, rootletin
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DCHS2 dachsous cadherin-related 2
DENND3 DENN/MADD domain containing 3
DMPK dystrophia myotonica-protein kinase
DOCK9 dedicator of cytokinesis 9
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DSG3 desmoglein 3
DTNB dystrobrevin, beta
EFR3B EFR3 homolog B (S. cerevisiae)
EGR2 early growth response 2
EXPH5 exophilin 5
FAIM2 Fas apoptotic inhibitory molecule 2
FGF6 fibroblast growth factor 6
FOXF1 forkhead box F1
FZD5 frizzled class receptor 5
GRK4 G protein-coupled receptor kinase 4
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HPSE2 heparanase 2 (inactive)
IL36R interleukin 36 receptor
JAM3 junctional adhesion molecule 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KLF1 Kruppel-like factor 1 (erythroid)
KLHL35 kelch-like family member 35
KLRC4 killer cell lectin-like receptor subfamily C, member 4
L1CAM L1 cell adhesion molecule
LAMB4 laminin, beta 4
LEF1 lymphoid enhancer-binding factor 1
LIMCH1 LIM and calponin homology domains 1
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
MCPH1 microcephalin 1
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1L metastasis suppressor 1-like
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEK1 NIMA-related kinase 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPY2R neuropeptide Y receptor Y2
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
PADI3 peptidyl arginine deiminase, type III
PDAP1 PDGFA associated protein 1
PDPN podoplanin
PEAK1 pseudopodium-enriched atypical kinase 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PODNL1 podocan-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB1 proline-rich protein BstNI subfamily 1
PSCA prostate stem cell antigen
PSG5 pregnancy specific beta-1-glycoprotein 5
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PVRIG poliovirus receptor related immunoglobulin domain containing
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SIPA1 signal-induced proliferation-associated 1
STAT4 signal transducer and activator of transcription 4
SUGP1 SURP and G patch domain containing 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TUBA4B tubulin, alpha 4b
TXNRD2 thioredoxin reductase 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VGLL3 vestigial-like family member 3
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
ZFPL1 zinc finger protein-like 1

decreased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
ADCY7 adenylate cyclase 7
AGMAT agmatine ureohydrolase (agmatinase)
AMT aminomethyltransferase
AOC2 amine oxidase, copper containing 2 (retina-specific)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
C17ORF53 chromosome 17 open reading frame 53
C19ORF73 chromosome 19 open reading frame 73
C1ORF54 chromosome 1 open reading frame 54
CCDC15 coiled-coil domain containing 15
CD82 CD82 molecule
CES3 carboxylesterase 3
CLDN1 claudin 1
CORO7 coronin 7
CPB1 carboxypeptidase B1 (tissue)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA3 ephrin-A3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EML4 echinoderm microtubule associated protein like 4
FAM155A family with sequence similarity 155, member A
FAM160B2 family with sequence similarity 160, member B2
FAM76A family with sequence similarity 76, member A
FBXO22 F-box protein 22
FIP1L1 factor interacting with PAPOLA and CPSF1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HIRA histone cell cycle regulator
HIST1H2BO histone cluster 1, H2bo
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
IFNA17 interferon, alpha 17
IFT54 intraflagellar transport 54
INHA inhibin, alpha
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIAA1024 KIAA1024
LATS1 large tumor suppressor kinase 1
LHX1 LIM homeobox 1
LOC729164 hCG1732469
LRRC20 leucine rich repeat containing 20
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
MAST3 microtubule associated serine/threonine kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MDM4 MDM4, p53 regulator
MMP2 matrix metallopeptidase 2
MOB3B MOB kinase activator 3B
MOCS3 molybdenum cofactor synthesis 3
NDOR1 NADPH dependent diflavin oxidoreductase 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSGIN1 oxidative stress induced growth inhibitor 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PARG poly (ADP-ribose) glycohydrolase
PEX26 peroxisomal biogenesis factor 26
PHF14 PHD finger protein 14
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POPDC3 popeye domain containing 3
PRKCE protein kinase C, epsilon
PSG4 pregnancy specific beta-1-glycoprotein 4
QPCTL glutaminyl-peptide cyclotransferase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM41 RNA binding motif protein 41
RNF126P1 ring finger protein 126 pseudogene 1
RNF43 ring finger protein 43
SENP7 SUMO1/sentrin specific peptidase 7
SETD8 SET domain containing (lysine methyltransferase) 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNCAIP synuclein, alpha interacting protein
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYCP2 synaptonemal complex protein 2
SYNC syncoilin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THRAP3 thyroid hormone receptor associated protein 3
TMEM209 transmembrane protein 209
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
WDR33 WD repeat domain 33
ZBTB22 zinc finger and BTB domain containing 22
ZBTB38 zinc finger and BTB domain containing 38
ZNF134 zinc finger protein 134
ZNF253 zinc finger protein 253
ZNF480 zinc finger protein 480
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZSWIM1 zinc finger, SWIM-type containing 1