tolazamide-2482 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the tolazamide-2482 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABI3BP ABI family, member 3 (NESH) binding protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ATAT1 alpha tubulin acetyltransferase 1
ATP10A ATPase, class V, type 10A
BARX1 BARX homeobox 1
C21ORF2 chromosome 21 open reading frame 2
CABP1 calcium binding protein 1
CAPN9 calpain 9
CCL27 chemokine (C-C motif) ligand 27
CDC14B cell division cycle 14B
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CIB2 calcium and integrin binding family member 2
CLMN calmin (calponin-like, transmembrane)
CNGB3 cyclic nucleotide gated channel beta 3
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
DAPK3 death-associated protein kinase 3
DFNB31 deafness, autosomal recessive 31
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DIO2 deiodinase, iodothyronine, type II
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EPS8L1 EPS8-like 1
EXOSC2 exosome component 2
FGB fibrinogen beta chain
FN1 fibronectin 1
FRMD4B FERM domain containing 4B
GK2 glycerol kinase 2
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GOLGA2P5 golgin A2 pseudogene 5
GPR107 G protein-coupled receptor 107
GRM6 glutamate receptor, metabotropic 6
GTDC1 glycosyltransferase-like domain containing 1
HIST1H4A histone cluster 1, H4a
IL5RA interleukin 5 receptor, alpha
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF3 Kruppel-like factor 3 (basic)
LECT1 leukocyte cell derived chemotaxin 1
LEFTY1 left-right determination factor 1
LENEP lens epithelial protein
LTBP2 latent transforming growth factor beta binding protein 2
MAL mal, T-cell differentiation protein
MAPK7 mitogen-activated protein kinase 7
MED25 mediator complex subunit 25
MLXIPL MLX interacting protein-like
MYO6 myosin VI
NCKAP1L NCK-associated protein 1-like
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEUROD1 neuronal differentiation 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFML2B olfactomedin-like 2B
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDCD6 programmed cell death 6
PDE11A phosphodiesterase 11A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4DIP phosphodiesterase 4D interacting protein
PHF3 PHD finger protein 3
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PPP1R26 protein phosphatase 1, regulatory subunit 26
PRPH peripherin
PSG1 pregnancy specific beta-1-glycoprotein 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RANBP1 RAN binding protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS3 regulator of G-protein signaling 3
RPL10 ribosomal protein L10
RPL7 ribosomal protein L7
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SH2D3A SH2 domain containing 3A
SIRPA signal-regulatory protein alpha
SIRT4 sirtuin 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLN sarcolipin
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOGA1 suppressor of glucose, autophagy associated 1
SRSF7 serine/arginine-rich splicing factor 7
SSH3 slingshot protein phosphatase 3
STAB1 stabilin 1
TAGLN3 transgelin 3
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBCD tubulin folding cofactor D
TCP11L1 t-complex 11, testis-specific-like 1
TEF thyrotrophic embryonic factor
THBD thrombomodulin
TNNT3 troponin T type 3 (skeletal, fast)
TRGV5 T cell receptor gamma variable 5
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTLL7 tubulin tyrosine ligase-like family member 7
WDR25 WD repeat domain 25
ZC3H7B zinc finger CCCH-type containing 7B
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACP6 acid phosphatase 6, lysophosphatidic
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAM15 ADAM metallopeptidase domain 15
ALS2CL ALS2 C-terminal like
AMDHD2 amidohydrolase domain containing 2
ANKRD55 ankyrin repeat domain 55
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOO apolipoprotein O
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASAP1-IT1 ASAP1 intronic transcript 1
BTBD2 BTB (POZ) domain containing 2
C12ORF49 chromosome 12 open reading frame 49
C1ORF56 chromosome 1 open reading frame 56
C7ORF43 chromosome 7 open reading frame 43
C9ORF3 chromosome 9 open reading frame 3
CCDC47 coiled-coil domain containing 47
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CLCN2 chloride channel, voltage-sensitive 2
CLSPN claspin
CRY2 cryptochrome circadian clock 2
DCAF13 DDB1 and CUL4 associated factor 13
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFNA3 ephrin-A3
EMILIN2 elastin microfibril interfacer 2
ERO1LB ERO1-like beta (S. cerevisiae)
FLCN folliculin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GK3P glycerol kinase 3 pseudogene
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR63 G protein-coupled receptor 63
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HMGB3P1 high mobility group box 3 pseudogene 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL11RA interleukin 11 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
IPO8 importin 8
KCTD20 potassium channel tetramerization domain containing 20
KDM5C lysine (K)-specific demethylase 5C
KLF1 Kruppel-like factor 1 (erythroid)
LRRC37A3 leucine rich repeat containing 37, member A3
MBTD1 mbt domain containing 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP9 matrix metallopeptidase 9
MREG melanoregulin
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NSUN6 NOP2/Sun domain family, member 6
NT5DC3 5'-nucleotidase domain containing 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PGM3 phosphoglucomutase 3
PHACTR4 phosphatase and actin regulator 4
PLCD1 phospholipase C, delta 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PRR7 proline rich 7 (synaptic)
RAB23 RAB23, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RHOBTB1 Rho-related BTB domain containing 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF122 ring finger protein 122
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
RWDD3 RWD domain containing 3
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SNIP1 Smad nuclear interacting protein 1
SPAG1 sperm associated antigen 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK4 serine/threonine kinase 4
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYCP2 synaptonemal complex protein 2
TAS2R10 taste receptor, type 2, member 10
TBC1D19 TBC1 domain family, member 19
TEC tec protein tyrosine kinase
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM209 transmembrane protein 209
TOLLIP toll interacting protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
YY2 YY2 transcription factor
ZNF134 zinc finger protein 134
ZNF273 zinc finger protein 273
ZNF345 zinc finger protein 345
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF747 zinc finger protein 747
ZSCAN16 zinc finger and SCAN domain containing 16