tolazamide-4003 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the tolazamide-4003 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACVR1B activin A receptor, type IB
AKAP5 A kinase (PRKA) anchor protein 5
ANP32A-IT1 ANP32A intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG10 autophagy related 10
B9D1 B9 protein domain 1
BCL2 B-cell CLL/lymphoma 2
BEND5 BEN domain containing 5
C11ORF16 chromosome 11 open reading frame 16
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHRM5 cholinergic receptor, muscarinic 5
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CXCL8 chemokine (C-X-C motif) ligand 8
DGKE diacylglycerol kinase, epsilon 64kDa
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOHH deoxyhypusine hydroxylase/monooxygenase
DPY19L1P1 DPY19L1 pseudogene 1
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EML3 echinoderm microtubule associated protein like 3
EXOC7 exocyst complex component 7
FAS Fas cell surface death receptor
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GBP1 guanylate binding protein 1, interferon-inducible
GOSR2 golgi SNAP receptor complex member 2
GSK3A glycogen synthase kinase 3 alpha
HEMK1 HemK methyltransferase family member 1
HIPK3 homeodomain interacting protein kinase 3
HLA-DOB major histocompatibility complex, class II, DO beta
ICAM1 intercellular adhesion molecule 1
IHH indian hedgehog
IL32 interleukin 32
IL6 interleukin 6
KIF1C kinesin family member 1C
KLF4 Kruppel-like factor 4 (gut)
MAGEA8 melanoma antigen family A8
MAP1B microtubule-associated protein 1B
MAP7D3 MAP7 domain containing 3
MDM4 MDM4, p53 regulator
MEF2C myocyte enhancer factor 2C
MTMR1 myotubularin related protein 1
MYO15A myosin XVA
NFX1 nuclear transcription factor, X-box binding 1
NRF1 nuclear respiratory factor 1
OAZ3 ornithine decarboxylase antizyme 3
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDH11Y protocadherin 11 Y-linked
PCDH7 protocadherin 7
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PKP4 plakophilin 4
PLCD1 phospholipase C, delta 1
PMEL premelanosome protein
PPARD peroxisome proliferator-activated receptor delta
PRKCI protein kinase C, iota
PRKG1 protein kinase, cGMP-dependent, type I
PTBP3 polypyrimidine tract binding protein 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRR protein tyrosine phosphatase, receptor type, R
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOS2 son of sevenless homolog 2 (Drosophila)
SOX15 SRY (sex determining region Y)-box 15
SPANXC SPANX family, member C
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
THRB thyroid hormone receptor, beta
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM63A transmembrane protein 63A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TREM1 triggering receptor expressed on myeloid cells 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VNN1 vanin 1
WNK1 WNK lysine deficient protein kinase 1
XYLB xylulokinase homolog (H. influenzae)
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFPL1 zinc finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF688 zinc finger protein 688

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BFSP1 beaded filament structural protein 1, filensin
BMP15 bone morphogenetic protein 15
BNC1 basonuclin 1
BST1 bone marrow stromal cell antigen 1
C11ORF30 chromosome 11 open reading frame 30
C14ORF105 chromosome 14 open reading frame 105
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD68 CD68 molecule
CEL carboxyl ester lipase
CENPJ centromere protein J
CHI3L2 chitinase 3-like 2
CINP cyclin-dependent kinase 2 interacting protein
CLDN15 claudin 15
COL9A3 collagen, type IX, alpha 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
DBF4B DBF4 zinc finger B
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DNM3 dynamin 3
EDAR ectodysplasin A receptor
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPN1 epsin 1
EXO5 exonuclease 5
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM186A family with sequence similarity 186, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GNA14 guanine nucleotide binding protein (G protein), alpha 14
H1F0 H1 histone family, member 0
H2AFJ H2A histone family, member J
HIST1H1T histone cluster 1, H1t
HIST1H3A histone cluster 1, H3a
IFNA17 interferon, alpha 17
IL1R1 interleukin 1 receptor, type I
IL4R interleukin 4 receptor
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KDM8 lysine (K)-specific demethylase 8
KIAA1107 KIAA1107
KIAA1456 KIAA1456
LMNB1 lamin B1
LOC729164 hCG1732469
LPPR1 lipid phosphate phosphatase-related protein type 1
LYPD3 LY6/PLAUR domain containing 3
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MED31 mediator complex subunit 31
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
MYO1F myosin IF
NAG18 NAG18 mRNA
NID2 nidogen 2 (osteonidogen)
NIPAL2 NIPA-like domain containing 2
NT5M 5',3'-nucleotidase, mitochondrial
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OSBP2 oxysterol binding protein 2
PADI1 peptidyl arginine deiminase, type I
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE12 phosphodiesterase 12
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLBD1 phospholipase B domain containing 1
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRR15L proline rich 15-like
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPRS protein tyrosine phosphatase, receptor type, S
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGCC regulator of cell cycle
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLAMF7 SLAM family member 7
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC46A3 solute carrier family 46, member 3
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SNORA21 small nucleolar RNA, H/ACA box 21
SPTBN2 spectrin, beta, non-erythrocytic 2
SSTR4 somatostatin receptor 4
STARD3 StAR-related lipid transfer (START) domain containing 3
STARD5 StAR-related lipid transfer (START) domain containing 5
STIM1 stromal interaction molecule 1
TDRKH tudor and KH domain containing
TENM4 teneurin transmembrane protein 4
TESPA1 thymocyte expressed, positive selection associated 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM212 transmembrane protein 212
TSNAXIP1 translin-associated factor X interacting protein 1
WDR25 WD repeat domain 25
WNT1 wingless-type MMTV integration site family, member 1
ZNF268 zinc finger protein 268
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF442 zinc finger protein 442