tolazoline-2000 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tolazoline-2000 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ADCY7 adenylate cyclase 7
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
APAF1 apoptotic peptidase activating factor 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ATP9B ATPase, class II, type 9B
ATXN7 ataxin 7
BBS1 Bardet-Biedl syndrome 1
BCL3 B-cell CLL/lymphoma 3
BCLAF1 BCL2-associated transcription factor 1
C19ORF66 chromosome 19 open reading frame 66
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALHM2 calcium homeostasis modulator 2
CCPG1 cell cycle progression 1
CD34 CD34 molecule
CD69 CD69 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEL carboxyl ester lipase
CEP70 centrosomal protein 70kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTSB cathepsin B
CTSZ cathepsin Z
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EID1 EP300 interacting inhibitor of differentiation 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPS15 epidermal growth factor receptor pathway substrate 15
ERLIN2 ER lipid raft associated 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
FURIN furin (paired basic amino acid cleaving enzyme)
GAS7 growth arrest-specific 7
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR183 G protein-coupled receptor 183
GPSM2 G-protein signaling modulator 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBEGF heparin-binding EGF-like growth factor
HIRA histone cell cycle regulator
HIST1H2AC histone cluster 1, H2ac
HLA-DOA major histocompatibility complex, class II, DO alpha
IDS iduronate 2-sulfatase
ING4 inhibitor of growth family, member 4
ITM2B integral membrane protein 2B
KANK2 KN motif and ankyrin repeat domains 2
KIFC1 kinesin family member C1
MAGT1 magnesium transporter 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K5 mitogen-activated protein kinase kinase 5
MED13L mediator complex subunit 13-like
MGAM maltase-glucoamylase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGFRL1 opioid growth factor receptor-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PLSCR1 phospholipid scramblase 1
PNISR PNN-interacting serine/arginine-rich protein
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRIM2 primase, DNA, polypeptide 2 (58kDa)
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RNF2 ring finger protein 2
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL14 ribosomal protein L14
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RSF1 remodeling and spacing factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SECISBP2L SECIS binding protein 2-like
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
SWAP70 SWAP switching B-cell complex 70kDa subunit
TJP2 tight junction protein 2
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC11 trafficking protein particle complex 11
UNC45A unc-45 homolog A (C. elegans)
WAS Wiskott-Aldrich syndrome
YIPF4 Yip1 domain family, member 4
ZC3H7B zinc finger CCCH-type containing 7B
ZNF250 zinc finger protein 250
ZNF292 zinc finger protein 292
ZNF32 zinc finger protein 32

decreased expression

Symbol Name
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANKHD1 ankyrin repeat and KH domain containing 1
ATXN2 ataxin 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAP31 B-cell receptor-associated protein 31
BCCIP BRCA2 and CDKN1A interacting protein
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
CA2 carbonic anhydrase II
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALCOCO2 calcium binding and coiled-coil domain 2
CDC123 cell division cycle 123
CDC45 cell division cycle 45
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COG7 component of oligomeric golgi complex 7
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCPS decapping enzyme, scavenger
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DOLK dolichol kinase
DPH2 DPH2 homolog (S. cerevisiae)
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERF Ets2 repressor factor
EXOSC5 exosome component 5
FADS2 fatty acid desaturase 2
FPGS folylpolyglutamate synthase
GARS glycyl-tRNA synthetase
GLOD4 glyoxalase domain containing 4
GMCL1 germ cell-less, spermatogenesis associated 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8B golgin A8 family, member B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPS1 G protein pathway suppressor 1
GSTM3 glutathione S-transferase mu 3 (brain)
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
ICT1 immature colon carcinoma transcript 1
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
KRI1 KRI1 homolog (S. cerevisiae)
LAMP5 lysosomal-associated membrane protein family, member 5
LAS1L LAS1-like (S. cerevisiae)
LRRK1 leucine-rich repeat kinase 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL4 mitochondrial ribosomal protein L4
MRPS34 mitochondrial ribosomal protein S34
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NTHL1 nth endonuclease III-like 1 (E. coli)
NUP93 nucleoporin 93kDa
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PES1 pescadillo ribosomal biogenesis factor 1
PFKM phosphofructokinase, muscle
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRMT5 protein arginine methyltransferase 5
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTGES2 prostaglandin E synthase 2
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RARS arginyl-tRNA synthetase
RNF113A ring finger protein 113A
RNH1 ribonuclease/angiogenin inhibitor 1
RPE ribulose-5-phosphate-3-epimerase
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUVBL2 RuvB-like AAA ATPase 2
SDF2L1 stromal cell-derived factor 2-like 1
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRM spermidine synthase
SRRD SRR1 domain containing
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAC SH3 and cysteine rich domain
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TERT telomerase reverse transcriptase
TEX264 testis expressed 264
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMED1 transmembrane emp24 protein transport domain containing 1
TTC4 tetratricopeptide repeat domain 4
UBA5 ubiquitin-like modifier activating enzyme 5
UBAC1 UBA domain containing 1
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
XPA xeroderma pigmentosum, complementation group A
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF263 zinc finger protein 263