tolfenamic acid-5454 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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191 genes differentially expressed following the tolfenamic acid-5454 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACAA2 acetyl-CoA acyltransferase 2
ACTC1 actin, alpha, cardiac muscle 1
ACVR1B activin A receptor, type IB
ADD2 adducin 2 (beta)
AKR1C1 aldo-keto reductase family 1, member C1
ANGEL2 angel homolog 2 (Drosophila)
APOE apolipoprotein E
APOL3 apolipoprotein L, 3
ARC activity-regulated cytoskeleton-associated protein
ATP10B ATPase, class V, type 10B
ATXN2L ataxin 2-like
BEX1 brain expressed, X-linked 1
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCDC85C coiled-coil domain containing 85C
CD200 CD200 molecule
CDHR1 cadherin-related family member 1
CLEC4M C-type lectin domain family 4, member M
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYLD cylindromatosis (turban tumor syndrome)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DMBT1 deleted in malignant brain tumors 1
DOCK9 dedicator of cytokinesis 9
EFNB3 ephrin-B3
ELL2 elongation factor, RNA polymerase II, 2
ERO1LB ERO1-like beta (S. cerevisiae)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF6 fibroblast growth factor 6
GLUD2 glutamate dehydrogenase 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GPR137 G protein-coupled receptor 137
GPR15 G protein-coupled receptor 15
HIC2 hypermethylated in cancer 2
HIST1H2AB histone cluster 1, H2ab
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HRH1 histamine receptor H1
IL9R interleukin 9 receptor
IQSEC2 IQ motif and Sec7 domain 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LIME1 Lck interacting transmembrane adaptor 1
LPL lipoprotein lipase
LPO lactoperoxidase
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBD2 methyl-CpG binding domain protein 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MPL MPL proto-oncogene, thrombopoietin receptor
MYO7A myosin VIIA
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUPR1 nuclear protein, transcriptional regulator, 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PCDHGA8 protocadherin gamma subfamily A, 8
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZD2 PDZ domain containing 2
PKDREJ polycystin (PKD) family receptor for egg jelly
PKP1 plakophilin 1
PKP2 plakophilin 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
POFUT2 protein O-fucosyltransferase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP4R4 protein phosphatase 4, regulatory subunit 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRM protein tyrosine phosphatase, receptor type, M
RERE arginine-glutamic acid dipeptide (RE) repeats
RFPL1S RFPL1 antisense RNA 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RUNX1 runt-related transcription factor 1
SH3BP2 SH3-domain binding protein 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SPTBN2 spectrin, beta, non-erythrocytic 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSTR4 somatostatin receptor 4
SYT5 synaptotagmin V
TBRG4 transforming growth factor beta regulator 4
TLE4 transducin-like enhancer of split 4
TRA T cell receptor alpha locus
TTLL7 tubulin tyrosine ligase-like family member 7
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPK3B uroplakin 3B
USP29 ubiquitin specific peptidase 29
VAV2 vav 2 guanine nucleotide exchange factor
VCX2 variable charge, X-linked 2
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB22 zinc finger and BTB domain containing 22

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACBD4 acyl-CoA binding domain containing 4
ADCY7 adenylate cyclase 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANP32A-IT1 ANP32A intronic transcript 1
APOLD1 apolipoprotein L domain containing 1
ASAP1-IT1 ASAP1 intronic transcript 1
BAHD1 bromo adjacent homology domain containing 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BFSP1 beaded filament structural protein 1, filensin
BHLHE41 basic helix-loop-helix family, member e41
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CAPN5 calpain 5
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CHKB choline kinase beta
CST6 cystatin E/M
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF10 DDB1 and CUL4 associated factor 10
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNMBP dynamin binding protein
DPY19L1P1 DPY19L1 pseudogene 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA2 EPH receptor A2
FAM169A family with sequence similarity 169, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA4 GATA binding protein 4
GRAMD4 GRAM domain containing 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1E histone cluster 1, H1e
HIST1H2BJ histone cluster 1, H2bj
HIST1H3G histone cluster 1, H3g
HOXC11 homeobox C11
HYI hydroxypyruvate isomerase (putative)
IFI6 interferon, alpha-inducible protein 6
IPO8 importin 8
ITPKB inositol-trisphosphate 3-kinase B
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0754 KIAA0754
KLC2 kinesin light chain 2
KLHL26 kelch-like family member 26
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMA3 laminin, alpha 3
LINC00597 long intergenic non-protein coding RNA 597
LOC100286895 cell division cycle 27 homolog pseudogene
MATK megakaryocyte-associated tyrosine kinase
MCOLN1 mucolipin 1
MEFV Mediterranean fever
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL52 mitochondrial ribosomal protein L52
MYO1F myosin IF
NPFFR1 neuropeptide FF receptor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHA9 protocadherin alpha 9
PDE12 phosphodiesterase 12
PHC1 polyhomeotic homolog 1 (Drosophila)
POLL polymerase (DNA directed), lambda
PRPH peripherin
RAB30 RAB30, member RAS oncogene family
RCAN3 RCAN family member 3
RFXAP regulatory factor X-associated protein
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF39 ring finger protein 39
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RUSC2 RUN and SH3 domain containing 2
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH2B3 SH2B adaptor protein 3
SMIM14 small integral membrane protein 14
SRD5A3 steroid 5 alpha-reductase 3
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D17 TBC1 domain family, member 17
TMEM45A transmembrane protein 45A
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC119 unc-119 homolog (C. elegans)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB48 zinc finger and BTB domain containing 48
ZNF136 zinc finger protein 136
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF268 zinc finger protein 268
ZNF324 zinc finger protein 324
ZNF74 zinc finger protein 74