tomatidine-1754 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the tomatidine-1754 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADCY6 adenylate cyclase 6
AKAP17A A kinase (PRKA) anchor protein 17A
ARFRP1 ADP-ribosylation factor related protein 1
ARHGAP1 Rho GTPase activating protein 1
ARTN artemin
BTF3P12 basic transcription factor 3 pseudogene 12
CA7 carbonic anhydrase VII
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CADM3 cell adhesion molecule 3
CD3D CD3d molecule, delta (CD3-TCR complex)
CES2 carboxylesterase 2
CHPF chondroitin polymerizing factor
CLCN7 chloride channel, voltage-sensitive 7
CNTN1 contactin 1
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DOCK4 dedicator of cytokinesis 4
ELMO2 engulfment and cell motility 2
ENG endoglin
EPS8L1 EPS8-like 1
EXD2 exonuclease 3'-5' domain containing 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FASTK Fas-activated serine/threonine kinase
FBXO42 F-box protein 42
FKBP2 FK506 binding protein 2, 13kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FNDC3A fibronectin type III domain containing 3A
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GFOD2 glucose-fructose oxidoreductase domain containing 2
GPR27 G protein-coupled receptor 27
HDAC5 histone deacetylase 5
HLA-DOA major histocompatibility complex, class II, DO alpha
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOOK2 hook microtubule-tethering protein 2
INA internexin neuronal intermediate filament protein, alpha
INO80D INO80 complex subunit D
INTS1 integrator complex subunit 1
ITGB5 integrin, beta 5
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRN2 leucine rich repeat neuronal 2
LUZP1 leucine zipper protein 1
MAD2L1BP MAD2L1 binding protein
MB myoglobin
MBOAT7 membrane bound O-acyltransferase domain containing 7
MLX MLX, MAX dimerization protein
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MTMR2 myotubularin related protein 2
MUC2 mucin 2, oligomeric mucus/gel-forming
MYO15B myosin XVB
NAAA N-acylethanolamine acid amidase
NDRG2 NDRG family member 2
OGFR opioid growth factor receptor
PEX10 peroxisomal biogenesis factor 10
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB2 phospholipase C, beta 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PSKH1 protein serine kinase H1
RAB26 RAB26, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SCAF4 SR-related CTD-associated factor 4
SDCCAG3 serologically defined colon cancer antigen 3
SGK2 serum/glucocorticoid regulated kinase 2
SHROOM2 shroom family member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TCP11L1 t-complex 11, testis-specific-like 1
TGIF2 TGFB-induced factor homeobox 2
TMEM70 transmembrane protein 70
TMPRSS6 transmembrane protease, serine 6
TOX4 TOX high mobility group box family member 4
TPD52L1 tumor protein D52-like 1
TRAPPC12 trafficking protein particle complex 12
TRMT61A tRNA methyltransferase 61A
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
UPK1A uroplakin 1A
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZC2HC1A zinc finger, C2HC-type containing 1A
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF460 zinc finger protein 460
ZNF764 zinc finger protein 764
ZNF778 zinc finger protein 778
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACIN1 apoptotic chromatin condensation inducer 1
ADAM23 ADAM metallopeptidase domain 23
ADGRA3 adhesion G protein-coupled receptor A3
AHR aryl hydrocarbon receptor
ANKRD46 ankyrin repeat domain 46
ATXN2 ataxin 2
BARD1 BRCA1 associated RING domain 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL10 B-cell CLL/lymphoma 10
BCOR BCL6 corepressor
C11ORF68 chromosome 11 open reading frame 68
C12ORF29 chromosome 12 open reading frame 29
C1D C1D nuclear receptor corepressor
CCDC176 coiled-coil domain containing 176
CCDC25 coiled-coil domain containing 25
CD9 CD9 molecule
CDK8 cyclin-dependent kinase 8
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLDN15 claudin 15
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
COMMD9 COMM domain containing 9
CS citrate synthase
DERL2 derlin 2
DRD5 dopamine receptor D5
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EFHC1 EF-hand domain (C-terminal) containing 1
ESYT1 extended synaptotagmin-like protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FAM222B family with sequence similarity 222, member B
FBXO5 F-box protein 5
FES FES proto-oncogene, tyrosine kinase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GTF2I general transcription factor IIi
HAGH hydroxyacylglutathione hydrolase
HDAC4 histone deacetylase 4
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL24 interleukin 24
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCTD3 potassium channel tetramerization domain containing 3
KDM7A lysine (K)-specific demethylase 7A
LMBR1L limb development membrane protein 1-like
LSP1 lymphocyte-specific protein 1
MAEA macrophage erythroblast attacher
MAK16 MAK16 homolog (S. cerevisiae)
MBIP MAP3K12 binding inhibitory protein 1
MEX3C mex-3 RNA binding family member C
MFSD11 major facilitator superfamily domain containing 11
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIS18BP1 MIS18 binding protein 1
MON1B MON1 secretory trafficking family member B
MTRF1 mitochondrial translational release factor 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NFE2 nuclear factor, erythroid 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRBF2 nuclear receptor binding factor 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUCB2 nucleobindin 2
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PARG poly (ADP-ribose) glycohydrolase
PEPD peptidase D
PEX26 peroxisomal biogenesis factor 26
PGPEP1 pyroglutamyl-peptidase I
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRCC papillary renal cell carcinoma (translocation-associated)
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTOV1 prostate tumor overexpressed 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB1B RAB1B, member RAS oncogene family
RNF11 ring finger protein 11
RPL13P5 ribosomal protein L13 pseudogene 5
RPS10P5 ribosomal protein S10 pseudogene 5
RPS14P3 ribosomal protein S14 pseudogene 3
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SERTAD3 SERTA domain containing 3
SNX15 sorting nexin 15
STAU2 staufen double-stranded RNA binding protein 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM156 transmembrane protein 156
TMEM164 transmembrane protein 164
TMEM45A transmembrane protein 45A
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
ZNF140 zinc finger protein 140
ZNF197 zinc finger protein 197
ZNF350 zinc finger protein 350
ZNF529 zinc finger protein 529