tomelukast-222 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the tomelukast-222 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACACA acetyl-CoA carboxylase alpha
ADAM12 ADAM metallopeptidase domain 12
ADARB1 adenosine deaminase, RNA-specific, B1
ADM2 adrenomedullin 2
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATF6B activating transcription factor 6 beta
BHMT betaine--homocysteine S-methyltransferase
BIN1 bridging integrator 1
C7ORF26 chromosome 7 open reading frame 26
CAPN9 calpain 9
CARTPT CART prepropeptide
CCHCR1 coiled-coil alpha-helical rod protein 1
CCNT2 cyclin T2
CDH22 cadherin 22, type 2
CDK10 cyclin-dependent kinase 10
CDKL3 cyclin-dependent kinase-like 3
CDYL chromodomain protein, Y-like
CLDN15 claudin 15
CLK1 CDC-like kinase 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COPZ2 coatomer protein complex, subunit zeta 2
CUL4A cullin 4A
CXXC4 CXXC finger protein 4
DIXDC1 DIX domain containing 1
DLEC1 deleted in lung and esophageal cancer 1
DNAH3 dynein, axonemal, heavy chain 3
DYSF dysferlin
FAM153A family with sequence similarity 153, member A
FAM188A family with sequence similarity 188, member A
FNDC3A fibronectin type III domain containing 3A
FUT2 fucosyltransferase 2 (secretor status included)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJB3 gap junction protein, beta 3, 31kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR173 G protein-coupled receptor 173
GTPBP4 GTP binding protein 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4J histone cluster 1, H4j
HOXC5 homeobox C5
IGSF9B immunoglobulin superfamily, member 9B
IL17A interleukin 17A
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KLF12 Kruppel-like factor 12
KRIT1 KRIT1, ankyrin repeat containing
KRT75 keratin 75, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LMF1 lipase maturation factor 1
MAOA monoamine oxidase A
MAPK8 mitogen-activated protein kinase 8
MCOLN1 mucolipin 1
MINK1 misshapen-like kinase 1
MOB3B MOB kinase activator 3B
MPZL2 myelin protein zero-like 2
MUC1 mucin 1, cell surface associated
MVB12B multivesicular body subunit 12B
MYL10 myosin, light chain 10, regulatory
PARVA parvin, alpha
PCDHB3 protocadherin beta 3
PCTP phosphatidylcholine transfer protein
PEX11A peroxisomal biogenesis factor 11 alpha
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB1 plexin B1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBFA ribosome binding factor A (putative)
RFPL2 ret finger protein-like 2
RIOK3 RIO kinase 3
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC22A17 solute carrier family 22, member 17
SMAD6 SMAD family member 6
STAU2 staufen double-stranded RNA binding protein 2
T T, brachyury homolog (mouse)
TCEA2 transcription elongation factor A (SII), 2
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGM5 transglutaminase 5
THEG theg spermatid protein
TMEM165 transmembrane protein 165
TOE1 target of EGR1, member 1 (nuclear)
TRAK1 trafficking protein, kinesin binding 1
WDR18 WD repeat domain 18
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YIPF4 Yip1 domain family, member 4
ZNF460 zinc finger protein 460
ZXDC ZXD family zinc finger C

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
AK5 adenylate kinase 5
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
APOB apolipoprotein B
ARMC4 armadillo repeat containing 4
ASIP agouti signaling protein
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATXN8OS ATXN8 opposite strand (non-protein coding)
BEST1 bestrophin 1
C1ORF54 chromosome 1 open reading frame 54
C8B complement component 8, beta polypeptide
CCDC30 coiled-coil domain containing 30
CCR7 chemokine (C-C motif) receptor 7
CD83 CD83 molecule
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLIP3 CAP-GLY domain containing linker protein 3
COBL cordon-bleu WH2 repeat protein
CST4 cystatin S
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCAF16 DDB1 and CUL4 associated factor 16
DCSTAMP dendrocyte expressed seven transmembrane protein
DEFB126 defensin, beta 126
DKFZP434C153 DKFZP434C153 protein
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
FBXO22 F-box protein 22
FCHSD2 FCH and double SH3 domains 2
FGFBP1 fibroblast growth factor binding protein 1
FXYD1 FXYD domain containing ion transport regulator 1
GDAP1 ganglioside induced differentiation associated protein 1
GDF2 growth differentiation factor 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HCG9 HLA complex group 9 (non-protein coding)
HOXD11 homeobox D11
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HUNK hormonally up-regulated Neu-associated kinase
HYAL3 hyaluronoglucosaminidase 3
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL13 interleukin 13
IL18RAP interleukin 18 receptor accessory protein
IL36RN interleukin 36 receptor antagonist
JAM3 junctional adhesion molecule 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KREMEN2 kringle containing transmembrane protein 2
LGALS13 lectin, galactoside-binding, soluble, 13
LIPG lipase, endothelial
LMTK1 lemur tail kinase 1
LOC100286895 cell division cycle 27 homolog pseudogene
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEB2 melanoma antigen family B2
MAPK3 mitogen-activated protein kinase 3
MARC1 mitochondrial amidoxime reducing component 1
MBNL3 muscleblind-like splicing regulator 3
MGC2889 uncharacterized protein MGC2889
MMP26 matrix metallopeptidase 26
MORC3 MORC family CW-type zinc finger 3
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYOZ1 myozenin 1
NXPH3 neurexophilin 3
ODF1 outer dense fiber of sperm tails 1
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OR2F2 olfactory receptor, family 2, subfamily F, member 2
OVOL1 ovo-like zinc finger 1
OXT oxytocin/neurophysin I prepropeptide
PDCD1 programmed cell death 1
PGBD5 piggyBac transposable element derived 5
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RBP1 retinol binding protein 1, cellular
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RPS4Y1 ribosomal protein S4, Y-linked 1
SAG S-antigen; retina and pineal gland (arrestin)
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETBP1 SET binding protein 1
SH2D2A SH2 domain containing 2A
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC6A16 solute carrier family 6, member 16
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLIT2 slit homolog 2 (Drosophila)
SYNGR4 synaptogyrin 4
THBS2 thrombospondin 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TSPAN7 tetraspanin 7
USF2 upstream transcription factor 2, c-fos interacting
WT1-AS WT1 antisense RNA
ZNF137P zinc finger protein 137, pseudogene
ZNF654 zinc finger protein 654