top1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description topoisomerase (DNA) I|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7150)
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Genes

20 genes co-occuring with the biological term top1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ATR ATR serine/threonine kinase
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BTBD1 BTB (POZ) domain containing 1
BTBD2 BTB (POZ) domain containing 2
DCLRE1B DNA cross-link repair 1B
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
MET MET proto-oncogene, receptor tyrosine kinase
MIR23A microRNA 23a
MUS81 MUS81 structure-specific endonuclease subunit
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
SLX4 SLX4 structure-specific endonuclease subunit
SUMO1 small ubiquitin-like modifier 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase