topiramate-915 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the topiramate-915 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ADCK2 aarF domain containing kinase 2
AHCYL2 adenosylhomocysteinase-like 2
APAF1 apoptotic peptidase activating factor 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BCORL1 BCL6 corepressor-like 1
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF95 chromosome 10 open reading frame 95
C14ORF79 chromosome 14 open reading frame 79
C4ORF29 chromosome 4 open reading frame 29
CCNT2 cyclin T2
CCP110 centriolar coiled coil protein 110kDa
CDC25C cell division cycle 25C
CEP131 centrosomal protein 131kDa
CEP290 centrosomal protein 290kDa
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTIF CBP80/20-dependent translation initiation factor
CXCL8 chemokine (C-X-C motif) ligand 8
DBT dihydrolipoamide branched chain transacylase E2
DCX doublecortin
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIAPH1 diaphanous-related formin 1
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FOXJ3 forkhead box J3
FZD1 frizzled class receptor 1
GID4 GID complex subunit 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GOLGA2 golgin A2
GOLGA4 golgin A4
GON4L gon-4-like (C. elegans)
GSK3A glycogen synthase kinase 3 alpha
HFE hemochromatosis
HIST1H4H histone cluster 1, H4h
INADL InaD-like (Drosophila)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0894 KIAA0894 protein
KLF11 Kruppel-like factor 11
KLHL21 kelch-like family member 21
LIN7A lin-7 homolog A (C. elegans)
MAP4 microtubule-associated protein 4
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC1 mucin 1, cell surface associated
NAAA N-acylethanolamine acid amidase
NCAM2 neural cell adhesion molecule 2
NEBL nebulette
NF1 neurofibromin 1
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIB nuclear factor I/B
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPEPPS aminopeptidase puromycin sensitive
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PKD2L2 polycystic kidney disease 2-like 2
PLK4 polo-like kinase 4
PPP5C protein phosphatase 5, catalytic subunit
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RABGAP1 RAB GTPase activating protein 1
REPS1 RALBP1 associated Eps domain containing 1
RGS12 regulator of G-protein signaling 12
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RNF216 ring finger protein 216
RPS28 ribosomal protein S28
SCAI suppressor of cancer cell invasion
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMG7 SMG7 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK11 serine/threonine kinase 11
SUMO1 small ubiquitin-like modifier 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
THBS3 thrombospondin 3
TM2D1 TM2 domain containing 1
TMPRSS3 transmembrane protease, serine 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TTLL3 tubulin tyrosine ligase-like family member 3
URGCP upregulator of cell proliferation
VLDLR very low density lipoprotein receptor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WNK1 WNK lysine deficient protein kinase 1
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZMYND8 zinc finger, MYND-type containing 8
ZNF14 zinc finger protein 14
ZNF227 zinc finger protein 227
ZNF268 zinc finger protein 268
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSF2 acyl-CoA synthetase family member 2
ACTL8 actin-like 8
AGO1 argonaute RISC catalytic component 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD40 ankyrin repeat domain 40
ANPEP alanyl (membrane) aminopeptidase
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAHD1 bromo adjacent homology domain containing 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C22ORF29 chromosome 22 open reading frame 29
C5AR2 complement component 5a receptor 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK20 cyclin-dependent kinase 20
CENPO centromere protein O
CHML choroideremia-like (Rab escort protein 2)
CORT cortistatin
CPTP ceramide-1-phosphate transfer protein
CRIP1 cysteine-rich protein 1 (intestinal)
CTC1 CTS telomere maintenance complex component 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DMTN dematin actin binding protein
DNM1 dynamin 1
DSE dermatan sulfate epimerase
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL7 EGF-like-domain, multiple 7
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELOVL4 ELOVL fatty acid elongase 4
FAM53B family with sequence similarity 53, member B
FBRS fibrosin
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR37L1 G protein-coupled receptor 37 like 1
HDAC7 histone deacetylase 7
HLA-J major histocompatibility complex, class I, J (pseudogene)
IFT81 intraflagellar transport 81
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KRT15 keratin 15, type I
LIME1 Lck interacting transmembrane adaptor 1
LRRC49 leucine rich repeat containing 49
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCOLN1 mucolipin 1
MRPL52 mitochondrial ribosomal protein L52
NLRX1 NLR family member X1
OFD1 oral-facial-digital syndrome 1
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PELI1 pellino E3 ubiquitin protein ligase 1
PMP22 peripheral myelin protein 22
POLH polymerase (DNA directed), eta
PRB3 proline-rich protein BstNI subfamily 3
PRPH peripherin
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB33B RAB33B, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
RBL1 retinoblastoma-like 1
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMD9 sterile alpha motif domain containing 9
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STX5 syntaxin 5
TDRD1 tudor domain containing 1
TGFB3 transforming growth factor, beta 3
TMEM51 transmembrane protein 51
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USB1 U6 snRNA biogenesis 1
VEGFC vascular endothelial growth factor C
WDR91 WD repeat domain 91
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF34 zinc finger protein 34
ZNF551 zinc finger protein 551
ZNHIT2 zinc finger, HIT-type containing 2