topotecan Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. (Chemical Entities of Biological Interest Ontology, CHEBI_63632)
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Genes

7 genes co-occuring with the biological term topotecan in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AQP5	aquaporin 5
MUC16	mucin 16, cell surface associated
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A
SLC22A8	solute carrier family 22 (organic anion transporter), member 8
TOP1	topoisomerase (DNA) I