| Dataset | LINCS L1000 CMAP Chemical Perturbation Consensus Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. (Chemical Entities of Biological Interest Ontology, CHEBI_63632) |
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4 genes differentially expressed following the topotecan small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SESN1 | sestrin 1 | 4.60752 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 4.13321 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.83304 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATF6 | activating transcription factor 6 | -3.09719 |
