toxicity Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

313 genes co-occuring with the biological term toxicity in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACO2 aconitase 2, mitochondrial
ADIPOR1 adiponectin receptor 1
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANXA5 annexin A5
APCS amyloid P component, serum
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID5B AT rich interactive domain 5B (MRF1-like)
AS3MT arsenite methyltransferase
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
ATN1 atrophin 1
ATP13A2 ATPase type 13A2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATXN1 ataxin 1
ATXN3 ataxin 3
ATXN7 ataxin 7
BAAT bile acid CoA:amino acid N-acyltransferase
BAK1 BCL2-antagonist/killer 1
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BMP7 bone morphogenetic protein 7
C9ORF72 chromosome 9 open reading frame 72
CACUL1 CDK2-associated, cullin domain 1
CAPN3 calpain 3, (p94)
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CD163 CD163 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD40LG CD40 ligand
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD8A CD8a molecule
CDA cytidine deaminase
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHMP2B charged multivesicular body protein 2B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLU clusterin
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSL cathepsin L
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DGKE diacylglycerol kinase, epsilon 64kDa
DHCR24 24-dehydrocholesterol reductase
DHODH dihydroorotate dehydrogenase (quinone)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB8 DnaJ (Hsp40) homolog, subfamily B, member 8
DNM1 dynamin 1
DPYD dihydropyrimidine dehydrogenase
DPYS dihydropyrimidinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUX4L1 double homeobox 4 like 1
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF3J eukaryotic translation initiation factor 3, subunit J
ENOSF1 enolase superfamily member 1
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
EWSR1 EWS RNA-binding protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF4 fibroblast growth factor 4
FKBP4 FK506 binding protein 4, 59kDa
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FPGS folylpolyglutamate synthase
FUS FUS RNA binding protein
FXN frataxin
GCDH glutaryl-CoA dehydrogenase
GDF15 growth differentiation factor 15
GFM2 G elongation factor, mitochondrial 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HAMP hepcidin antimicrobial peptide
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HP haptoglobin
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSF1 heat shock transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTT huntingtin
IAPP islet amyloid polypeptide
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IL2 interleukin 2
IL24 interleukin 24
IL6 interleukin 6
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INS insulin
INSR insulin receptor
ITM2B integral membrane protein 2B
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JPH3 junctophilin 3
JUN jun proto-oncogene
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
LIG3 ligase III, DNA, ATP-dependent
LRP1 low density lipoprotein receptor-related protein 1
LRRK2 leucine-rich repeat kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MARCH5 membrane-associated ring finger (C3HC4) 5
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MDK midkine (neurite growth-promoting factor 2)
MFN1 mitofusin 1
MFN2 mitofusin 2
MGP matrix Gla protein
MIR146A microRNA 146a
MIR196A2 microRNA 196a-2
MIR34A microRNA 34a
MMP2 matrix metallopeptidase 2
MPO myeloperoxidase
MT1A metallothionein 1A
MT2A metallothionein 2A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC16 mucin 16, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPTX1 neuronal pentraxin I
NPTX2 neuronal pentraxin II
NPTXR neuronal pentraxin receptor
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OGG1 8-oxoguanine DNA glycosylase
OPRM1 opioid receptor, mu 1
ORAI1 ORAI calcium release-activated calcium modulator 1
PABPN1 poly(A) binding protein, nuclear 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PFN1 profilin 1
PIKFYVE phosphoinositide kinase, FYVE finger containing
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PSEN1 presenilin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFC1 replication factor C (activator 1) 1, 145kDa
RHOA ras homolog family member A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRM1 ribonucleotide reductase M1
SCG2 secretogranin II
SCP2 sterol carrier protein 2
SEPP1 selenoprotein P, plasma, 1
SEPT5 septin 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN2 sestrin 2
SFTPA1 surfactant protein A1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A10 solute carrier family 30, member 10
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPAST spastin
SPP1 secreted phosphoprotein 1
SPRN shadow of prion protein homolog (zebrafish)
SQSTM1 sequestosome 1
STIM1 stromal interaction molecule 1
STK17A serine/threonine kinase 17a
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TARDBP TAR DNA binding protein
TBP TATA box binding protein
TDG thymine-DNA glycosylase
TF transferrin
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TPMT thiopurine S-methyltransferase
TRAP1 TNF receptor-associated protein 1
TRIP10 thyroid hormone receptor interactor 10
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSPO translocator protein (18kDa)
TTR transthyretin
TYMS thymidylate synthetase
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UMPS uridine monophosphate synthetase
UNG uracil-DNA glycosylase
UPB1 ureidopropionase, beta
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
WRN Werner syndrome, RecQ helicase-like
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H14 zinc finger CCCH-type containing 14
ZFAND2B zinc finger, AN1-type domain 2B
ZMPSTE24 zinc metallopeptidase STE24