toxicity Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

174 proteins co-occuring with the biological term toxicity in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APP amyloid beta (A4) precursor protein
AQP2 aquaporin 2 (collecting duct)
AR androgen receptor
ARFIP2 ADP-ribosylation factor interacting protein 2
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATXN1 ataxin 1
AURKA aurora kinase A
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCND3 cyclin D3
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CREB1 cAMP responsive element binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
CTTN cortactin
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DPYSL2 dihydropyrimidinase-like 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK1 ELK1, member of ETS oncogene family
ERBB3 erb-b2 receptor tyrosine kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FANCA Fanconi anemia, complementation group A
FCRL6 Fc receptor-like 6
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRK fyn-related Src family tyrosine kinase
GJA1 gap junction protein, alpha 1, 43kDa
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
HDAC6 histone deacetylase 6
HIST1H2BB histone cluster 1, H2bb
HIST1H3A histone cluster 1, H3a
HSF1 heat shock transcription factor 1
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
ITGB4 integrin, beta 4
JUN jun proto-oncogene
KDR kinase insert domain receptor
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLRF1 killer cell lectin-like receptor subfamily F, member 1
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LCK LCK proto-oncogene, Src family tyrosine kinase
LRRK2 leucine-rich repeat kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEF2D myocyte enhancer factor 2D
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NBN nibrin
NEFL neurofilament, light polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PFN1 profilin 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXN paxillin
RAD17 RAD17 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMC1A structural maintenance of chromosomes 1A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STMN1 stathmin 1
SYK spleen tyrosine kinase
SYN1 synapsin I
TACC3 transforming, acidic coiled-coil containing protein 3
TARDBP TAR DNA binding protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIGIT T cell immunoreceptor with Ig and ITIM domains
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TWIST1 twist family bHLH transcription factor 1
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
WWOX WW domain containing oxidoreductase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFP36 ZFP36 ring finger protein