toxoplasmosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia. (Human Disease Ontology, DOID_9965)
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Genes

180 genes co-occuring with the disease toxoplasmosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD4 CD4 molecule 2.03831
CD79A CD79a molecule, immunoglobulin-associated alpha 1.92811
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 1.62381
DHFR dihydrofolate reductase 1.17636
BAG1 BCL2-associated athanogene 1.17249
CD9 CD9 molecule 1.17078
OR2G2 olfactory receptor, family 2, subfamily G, member 2 1.16778
ADK adenosine kinase 1.12108
CENPV centromere protein V 1.10468
CD99 CD99 molecule 1.09041
TSPO translocator protein (18kDa) 1.06186
RHCE Rh blood group, CcEe antigens 1.0303
IFNG interferon, gamma 1.00499
STAB2 stabilin 2 0.994017
TOX thymocyte selection-associated high mobility group box 0.993596
ZNF35 zinc finger protein 35 0.926279
TOX4 TOX high mobility group box family member 4 0.921736
FDXR ferredoxin reductase 0.915551
RHD Rh blood group, D antigen 0.892538
IDO1 indoleamine 2,3-dioxygenase 1 0.881062
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.863865
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.859771
LUC7L LUC7-like (S. cerevisiae) 0.840115
IL2 interleukin 2 0.834788
BAG5 BCL2-associated athanogene 5 0.763086
TES testin LIM domain protein 0.749237
SNRPF small nuclear ribonucleoprotein polypeptide F 0.736649
TNF tumor necrosis factor 0.735027
IL10 interleukin 10 0.718039
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.710378
MCM8 minichromosome maintenance complex component 8 0.689492
MYD88 myeloid differentiation primary response 88 0.664769
NELFCD negative elongation factor complex member C/D 0.649323
SAG S-antigen; retina and pineal gland (arrestin) 0.631598
EXTL3 exostosin-like glycosyltransferase 3 0.610057
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.606152
TBX21 T-box 21 0.598351
CD40 CD40 molecule, TNF receptor superfamily member 5 0.588222
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.574994
OXSM 3-oxoacyl-ACP synthase, mitochondrial 0.571884
MMD2 monocyte to macrophage differentiation-associated 2 0.526518
CARTPT CART prepropeptide 0.507273
CECR1 cat eye syndrome chromosome region, candidate 1 0.505356
FDPS farnesyl diphosphate synthase 0.497321
CD40LG CD40 ligand 0.479047
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.473361
PFN4 profilin family, member 4 0.467684
LY75 lymphocyte antigen 75 0.46466
BSX brain-specific homeobox 0.463149
GOLIM4 golgi integral membrane protein 4 0.456355
TLR2 toll-like receptor 2 0.453339
HSPA4 heat shock 70kDa protein 4 0.447311
GGPS1 geranylgeranyl diphosphate synthase 1 0.442418
ERAP1 endoplasmic reticulum aminopeptidase 1 0.433397
TRIO trio Rho guanine nucleotide exchange factor 0.431519
DHPS deoxyhypusine synthase 0.42814
DERA deoxyribose-phosphate aldolase (putative) 0.423265
CATSPER1 cation channel, sperm associated 1 0.42289
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.421016
ZNF77 zinc finger protein 77 0.416896
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.415773
PFN1 profilin 1 0.409787
ALB albumin 0.401945
PFN2 profilin 2 0.401945
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.398216
OVGP1 oviductal glycoprotein 1, 120kDa 0.387423
SUB1 SUB1 homolog (S. cerevisiae) 0.383708
TLR9 toll-like receptor 9 0.374068
HLA-B major histocompatibility complex, class I, B 0.373698
THAP3 THAP domain containing, apoptosis associated protein 3 0.369628
B2M beta-2-microglobulin 0.368888
HIST1H1C histone cluster 1, H1c 0.339806
NT5C 5', 3'-nucleotidase, cytosolic 0.335046
ALPPL2 alkaline phosphatase, placental-like 2 0.333949
ALPP alkaline phosphatase, placental 0.333583
ALPL alkaline phosphatase, liver/bone/kidney 0.332852
TLR4 toll-like receptor 4 0.32701
AKR1D1 aldo-keto reductase family 1, member D1 0.325552
CNST consortin, connexin sorting protein 0.324094
IL6 interleukin 6 0.319363
ICAM1 intercellular adhesion molecule 1 0.318999
HLA-C major histocompatibility complex, class I, C 0.316819
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.313915
SRCIN1 SRC kinase signaling inhibitor 1 0.311739
CCL3 chemokine (C-C motif) ligand 3 0.311377
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.310652
SOCS2 suppressor of cytokine signaling 2 0.309566
CCL2 chemokine (C-C motif) ligand 2 0.307757
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.307395
ART3 ADP-ribosyltransferase 3 0.302698
IRF8 interferon regulatory factor 8 0.302337
AHR aryl hydrocarbon receptor 0.298371
ART1 ADP-ribosyltransferase 1 0.298371
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.293334
MYRF myelin regulatory factor 0.288668
CCR2 chemokine (C-C motif) receptor 2 0.28831
UNC93B1 unc-93 homolog B1 (C. elegans) 0.28616
IL4 interleukin 4 0.282582
ATG7 autophagy related 7 0.280796
DEFA5 defensin, alpha 5, Paneth cell-specific 0.279724
GBP1 guanylate binding protein 1, interferon-inducible 0.267622
CD34 CD34 molecule 0.263722
LCK LCK proto-oncogene, Src family tyrosine kinase 0.258417
GLB1 galactosidase, beta 1 0.257711
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.254888
TICAM2 toll-like receptor adaptor molecule 2 0.253831
CD59 CD59 molecule, complement regulatory protein 0.251015
SKP1 S-phase kinase-associated protein 1 0.240847
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.238054
IL27RA interleukin 27 receptor, alpha 0.236312
CSN1S1 casein alpha s1 0.233878
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.224196
HLA-A major histocompatibility complex, class I, A 0.221793
CD244 CD244 molecule, natural killer cell receptor 2B4 0.221108
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.220081
CFD complement factor D (adipsin) 0.219398
ACTG1 actin gamma 1 0.217012
IVD isovaleryl-CoA dehydrogenase 0.216332
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.212945
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.212271
ALYREF Aly/REF export factor 0.212271
HAT1 histone acetyltransferase 1 0.210253
SNORA29 small nucleolar RNA, H/ACA box 29 0.207912
CD80 CD80 molecule 0.20658
CRP C-reactive protein, pentraxin-related 0.206248
CD276 CD276 molecule 0.205916
S100A9 S100 calcium binding protein A9 0.205254
STIL SCL/TAL1 interrupting locus 0.203275
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.200006
ICOSLG inducible T-cell co-stimulator ligand 0.199356
POU3F4 POU class 3 homeobox 4 0.197099
GGT1 gamma-glutamyltransferase 1 0.188938
CTSL cathepsin L 0.185313
GSTA3 glutathione S-transferase alpha 3 0.185016
COL2A1 collagen, type II, alpha 1 0.184424
GSTA2 glutathione S-transferase alpha 2 0.183835
GSTA4 glutathione S-transferase alpha 4 0.182957
ATG5 autophagy related 5 0.182086
PKLR pyruvate kinase, liver and RBC 0.181798
GSTA1 glutathione S-transferase alpha 1 0.178682
CCL21 chemokine (C-C motif) ligand 21 0.177851
STYK1 serine/threonine/tyrosine kinase 1 0.177713
HES2 hes family bHLH transcription factor 2 0.177029
SIX6 SIX homeobox 6 0.176757
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.172928
TYMS thymidylate synthetase 0.172291
IRAK4 interleukin-1 receptor-associated kinase 4 0.17141
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.171286
NGDN neuroguidin, EIF4E binding protein 0.170299
CCL5 chemokine (C-C motif) ligand 5 0.168148
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.166544
TPRG1L tumor protein p63 regulated 1-like 0.166544
FLNB filamin B, beta 0.165545
DYNLRB1 dynein, light chain, roadblock-type 1 0.165435
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.164786
DRD1 dopamine receptor D1 0.163833
HIST2H2AC histone cluster 2, H2ac 0.163111
HIST2H2AA4 histone cluster 2, H2aa4 0.162908
HIST2H2AA3 histone cluster 2, H2aa3 0.162908
UPP1 uridine phosphorylase 1 0.162505
CXCL10 chemokine (C-X-C motif) ligand 10 0.162109
IFI30 interferon, gamma-inducible protein 30 0.161523
DRD5 dopamine receptor D5 0.15948
ACE angiotensin I converting enzyme 0.158434
RAG2 recombination activating gene 2 0.158266
ALOX12 arachidonate 12-lipoxygenase 0.152594
NRL neural retina leucine zipper 0.150476
WIPF2 WAS/WASL interacting protein family, member 2 0.148198
CHL1 cell adhesion molecule L1-like 0.146949
MLXIPL MLX interacting protein-like 0.146027
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.14432
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.143868
ADRB1 adrenoceptor beta 1 0.143787
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.143579
WDFY2 WD repeat and FYVE domain containing 2 0.143541
ANG angiogenin, ribonuclease, RNase A family, 5 0.14316
LARS leucyl-tRNA synthetase 0.143153
HLA-G major histocompatibility complex, class I, G 0.14268
MAOA monoamine oxidase A 0.141428
KRT18 keratin 18, type I 0.141149