tp53 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description tumor protein p53|This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013] (NCBI Entrez Gene Database, 7157)
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Genes

181 genes co-occuring with the biological term tp53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADGRB1 adhesion G protein-coupled receptor B1
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
APC adenomatous polyposis coli
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AR androgen receptor
ARID1A AT rich interactive domain 1A (SWI-like)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAALC brain and acute leukemia, cytoplasmic
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CA9 carbonic anhydrase IX
CCND1 cyclin D1
CCNE1 cyclin E1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHEK2 checkpoint kinase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCC DCC netrin 1 receptor
DCK deoxycytidine kinase
DDHD2 DDHD domain containing 2
DICER1 dicer 1, ribonuclease type III
DRD4 dopamine receptor D4
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FLT1 fms-related tyrosine kinase 1
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIC1 hypermethylated in cancer 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HRAS Harvey rat sarcoma viral oncogene homolog
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF2R insulin-like growth factor 2 receptor
IL10 interleukin 10
ITGB4 integrin, beta 4
KEAP1 kelch-like ECH-associated protein 1
KIF23 kinesin family member 23
KLF6 Kruppel-like factor 6
KLLN killin, p53-regulated DNA replication inhibitor
KMT2A lysine (K)-specific methyltransferase 2A
KMT2D lysine (K)-specific methyltransferase 2D
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MGMT O-6-methylguanine-DNA methyltransferase
MIR10B microRNA 10b
MIR1228 microRNA 1228
MIR125A microRNA 125a
MIR145 microRNA 145
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR17 microRNA 17
MIR181A2 microRNA 181a-2
MIR25 microRNA 25
MIR29A microRNA 29a
MIR30D microRNA 30d
MIR3151 microRNA 3151
MIR34A microRNA 34a
MIR34B microRNA 34b
MIR34C microRNA 34c
MIR491 microRNA 491
MIR502 microRNA 502
MIR98 microRNA 98
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRF1 nuclear respiratory factor 1
NT5C2 5'-nucleotidase, cytosolic II
NT5C3A 5'-nucleotidase, cytosolic IIIA
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
PCBP1 poly(rC) binding protein 1
PGR progesterone receptor
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCD protein kinase C, delta
PROM1 prominin 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTEN phosphatase and tensin homolog
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD51 RAD51 recombinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RLIM ring finger protein, LIM domain interacting
RPS6 ribosomal protein S6
RSF1 remodeling and spacing factor 1
RUNX3 runt-related transcription factor 3
S100A4 S100 calcium binding protein A4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SET SET nuclear proto-oncogene
SETD8 SET domain containing (lysine methyltransferase) 8
SF3B1 splicing factor 3b, subunit 1, 155kDa
SMAD4 SMAD family member 4
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SRSF3 serine/arginine-rich splicing factor 3
STK11 serine/threonine kinase 11
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TSG101 tumor susceptibility 101
TTK TTK protein kinase
TUSC3 tumor suppressor candidate 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WRAP53 WD repeat containing, antisense to TP53
WRN Werner syndrome, RecQ helicase-like
XPC xeroderma pigmentosum, complementation group C
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF280B zinc finger protein 280B
ZNF703 zinc finger protein 703