tradd Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TNFRSF1A-associated via death domain|The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8717)
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Genes

17 genes co-occuring with the biological term tradd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
FADD Fas (TNFRSF6)-associated via death domain
KRT14 keratin 14, type I
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
STAP2 signal transducing adaptor family member 2
TMC8 transmembrane channel-like 8
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRIP12 thyroid hormone receptor interactor 12