traf2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TNF receptor-associated factor 2|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7186)
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Genes

69 genes co-occuring with the biological term traf2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BCL2L1 BCL2-like 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRCA1 breast cancer 1, early onset
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CFLAR CASP8 and FADD-like apoptosis regulator
CHUK conserved helix-loop-helix ubiquitous kinase
COPS5 COP9 signalosome subunit 5
CYLD cylindromatosis (turban tumor syndrome)
DIABLO diablo, IAP-binding mitochondrial protein
EDARADD EDAR-associated death domain
FAS Fas cell surface death receptor
GSTP1 glutathione S-transferase pi 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL4 interleukin 4
JUN jun proto-oncogene
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MALT1 MALT1 paracaspase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MIR502 microRNA 502
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PARK2 parkin RBR E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASET2 ribonuclease T2
RPS3 ribosomal protein S3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SIVA1 SIVA1, apoptosis-inducing factor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPHK1 sphingosine kinase 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFG TRK-fused gene
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMC8 transmembrane channel-like 8
TNF tumor necrosis factor
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXN thioredoxin
USP2 ubiquitin specific peptidase 2
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP48 ubiquitin specific peptidase 48
ZC3H15 zinc finger CCCH-type containing 15