traf3 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TNF receptor-associated factor 3|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 7187)
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Genes

35 genes co-occuring with the biological term traf3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CD40 CD40 molecule, TNF receptor superfamily member 5
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIABLO diablo, IAP-binding mitochondrial protein
EDA2R ectodysplasin A2 receptor
IFNB1 interferon, beta 1, fibroblast
IFT54 intraflagellar transport 54
JUN jun proto-oncogene
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAVS mitochondrial antiviral signaling protein
MIR32 microRNA 32
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMRAL1 NmrA-like family domain containing 1
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
RETN resistin
RIPK2 receptor-interacting serine-threonine kinase 2
RNF216 ring finger protein 216
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TLR3 toll-like receptor 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF3IP3 TRAF3 interacting protein 3
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
ZMYND11 zinc finger, MYND-type containing 11