traf4 Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	TNF receptor-associated factor 4\|This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9618)
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Genes

13 genes co-occuring with the biological term traf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
AKT1	v-akt murine thymoma viral oncogene homolog 1
CD36	CD36 molecule (thrombospondin receptor)
CHUK	conserved helix-loop-helix ubiquitous kinase
GP1BB	glycoprotein Ib (platelet), beta polypeptide
MAP3K4	mitogen-activated protein kinase kinase kinase 4
MAPK9	mitogen-activated protein kinase 9
NOD2	nucleotide-binding oligomerization domain containing 2
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1
SMURF1	SMAD specific E3 ubiquitin protein ligase 1
TP63	tumor protein p63
TRAF2	TNF receptor-associated factor 2
TRAF4	TNF receptor-associated factor 4
TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase