traf6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description TNF receptor-associated factor 6, E3 ubiquitin protein ligase|The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 7189)
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Genes

112 genes co-occuring with the biological term traf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBRA1 autophagy/beclin-1 regulator 1
ATF1 activating transcription factor 1
BCAR1 breast cancer anti-estrogen resistance 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CARD11 caspase recruitment domain family, member 11
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CYB5A cytochrome b5 type A (microsomal)
CYBB cytochrome b-245, beta polypeptide
DCBLD2 discoidin, CUB and LCCL domain containing 2
EDARADD EDAR-associated death domain
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
FBXO31 F-box protein 31
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HTT huntingtin
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
JAK1 Janus kinase 1
KIF23 kinesin family member 23
LAT linker for activation of T cells
LGMN legumain
MALT1 MALT1 paracaspase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK8 mitogen-activated protein kinase 8
MARCH5 membrane-associated ring finger (C3HC4) 5
MAVS mitochondrial antiviral signaling protein
MIR125A microRNA 125a
MIR146A microRNA 146a
MMP13 matrix metallopeptidase 13
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NGF nerve growth factor (beta polypeptide)
NLRC3 NLR family, CARD domain containing 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NUMB numb homolog (Drosophila)
NUMBL numb homolog (Drosophila)-like
OTUD7B OTU deubiquitinase 7B
PARK7 parkinson protein 7
PELI2 pellino E3 ubiquitin protein ligase family member 2
PINK1 PTEN induced putative kinase 1
PRKCQ protein kinase C, theta
PSEN1 presenilin 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RANBP9 RAN binding protein 9
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RUSC1 RUN and SH3 domain containing 1
SARM1 sterile alpha and TIR motif containing 1
SDCBP syndecan binding protein (syntenin)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TANK TRAF family member-associated NFKB activator
TFG TRK-fused gene
TGFBR1 transforming growth factor, beta receptor 1
TICAM1 toll-like receptor adaptor molecule 1
TIFA TRAF-interacting protein with forkhead-associated domain
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXN thioredoxin
UBE2N ubiquitin-conjugating enzyme E2N
UBE2O ubiquitin-conjugating enzyme E2O
USP2 ubiquitin specific peptidase 2
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP48 ubiquitin specific peptidase 48
ZNF675 zinc finger protein 675