trans-Golgi network Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. (Gene Ontology, GO_0005802)
External Link http://amigo.geneontology.org/amigo/term/GO:0005802
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Genes

252 proteins localized to the trans-Golgi network cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
AFTPH aftiphilin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP1M2 adaptor-related protein complex 1, mu 2 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
AP4B1 adaptor-related protein complex 4, beta 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
AP4M1 adaptor-related protein complex 4, mu 1 subunit
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APP amyloid beta (A4) precursor protein
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARFIP1 ADP-ribosylation factor interacting protein 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ARFRP1 ADP-ribosylation factor related protein 1
ARL5A ADP-ribosylation factor-like 5A
ARL5B ADP-ribosylation factor-like 5B
ARL5C ADP-ribosylation factor-like 5C
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATG9A autophagy related 9A
ATG9B autophagy related 9B
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
ATP8B4 ATPase, class I, type 8B, member 4
ATP9A ATPase, class II, type 9A
ATP9B ATPase, class II, type 9B
ATXN2 ataxin 2
AZIN2 antizyme inhibitor 2
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BAIAP3 BAI1-associated protein 3
BICD1 bicaudal D homolog 1 (Drosophila)
BIRC6 baculoviral IAP repeat containing 6
BOK BCL2-related ovarian killer
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2
C17ORF75 chromosome 17 open reading frame 75
CA4 carbonic anhydrase IV
CABP7 calcium binding protein 7
CALN1 calneuron 1
CBY1 chibby homolog 1 (Drosophila)
CCDC186 coiled-coil domain containing 186
CCDC91 coiled-coil domain containing 91
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHID1 chitinase domain containing 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
CIMAP3 ciliary microtubule associated protein 3
CLASP2 cytoplasmic linker associated protein 2
CLBA1 clathrin binding box of aftiphilin containing 1
CLIP3 CAP-GLY domain containing linker protein 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CLVS1 clavesin 1
CLVS2 clavesin 2
CNST consortin, connexin sorting protein
COG1 component of oligomeric golgi complex 1
COG2 component of oligomeric golgi complex 2
COG3 component of oligomeric golgi complex 3
COG4 component of oligomeric golgi complex 4
COG5 component of oligomeric golgi complex 5
COG6 component of oligomeric golgi complex 6
COG7 component of oligomeric golgi complex 7
COG8 component of oligomeric golgi complex 8
CORO7-PAM16 CORO7-PAM16 readthrough
CRACR2A calcium release activated channel regulator 2A
DENND5A DENN/MADD domain containing 5A
DNAAF6 dynein axonemal assembly factor 6
DOP1A DOP1 leucine zipper like protein A
DOP1B DOP1 leucine zipper like protein B
DPY30 dpy-30 homolog (C. elegans)
ECPAS Ecm29 proteasome adaptor and scaffold
EIPR1 EARP complex and GARP complex interacting protein 1
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1
FAM91A1 family with sequence similarity 91, member A1
FCMR Fc fragment of IgM receptor
FURIN furin (paired basic amino acid cleaving enzyme)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GBA1 glucosylceramidase beta 1
GCC2 GRIP and coiled-coil domain containing 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GNAS GNAS complex locus
GOLGA1 golgin A1
GOLGA4 golgin A4
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GOLPH3L golgi phosphoprotein 3-like
GOLT1A golgi transport 1A
GPER1 G protein-coupled estrogen receptor 1
GPR108 G protein-coupled receptor 108
GRN granulin
GSAP gamma-secretase activating protein
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HOOK2 hook microtubule-tethering protein 2
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IGF2R insulin-like growth factor 2 receptor
INPP5K inositol polyphosphate-5-phosphatase K
KIF13A kinesin family member 13A
KLHL20 kelch-like family member 20
LAMP2 lysosomal-associated membrane protein 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LLGL1 lethal giant larvae homolog 1 (Drosophila)
M6PR mannose-6-phosphate receptor (cation dependent)
MARCHF1 membrane associated ring-CH-type finger 1
MARCHF4 membrane associated ring-CH-type finger 4
MARCHF9 membrane associated ring-CH-type finger 9
MICALL1 MICAL-like 1
MLANA melan-A
MMP12 matrix metallopeptidase 12
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E
MS4A7 membrane-spanning 4-domains, subfamily A, member 7
MYO18A myosin XVIIIA
MYO1B myosin IB
NBEA neurobeachin
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NSG1 neuron specific gene family member 1
NSG2 neuronal vesicle trafficking associated 2
OCRL oculocerebrorenal syndrome of Lowe
OPTN optineurin
OSBP oxysterol binding protein
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PHAF1 phagosome assembly factor 1
PHETA1 PH domain containing endocytic trafficking adaptor 1
PHETA2 PH domain containing endocytic trafficking adaptor 2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PICK1 protein interacting with PRKCA 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLD4 phospholipase D family, member 4
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLPP3 phospholipid phosphatase 3
POSTN periostin, osteoblast specific factor
PREPL prolyl endopeptidase-like
PRKD1 protein kinase D1
PTGES2 prostaglandin E synthase 2
RAB10 RAB10, member RAS oncogene family
RAB11A RAB11A, member RAS oncogene family
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB13 RAB13, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB3IP RAB3A interacting protein
RAB43 RAB43, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
RGPD1 RANBP2-like and GRIP domain containing 1
RGS20 regulator of G-protein signaling 20
RHOBTB3 Rho-related BTB domain containing 3
RIC1 RAB6A GEF complex partner 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCAMP1 secretory carrier membrane protein 1
SCAMP2 secretory carrier membrane protein 2
SCAMP3 secretory carrier membrane protein 3
SCAMP4 secretory carrier membrane protein 4
SCAMP5 secretory carrier membrane protein 5
SCOC short coiled-coil protein
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC30A6 solute carrier family 30 (zinc transporter), member 6
SLC39A9 solute carrier family 39, member 9
SLC66A2 solute carrier family 66 member 2
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SNX9 sorting nexin 9
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STX10 syntaxin 10
STX16 syntaxin 16
STX6 syntaxin 6
STX8 syntaxin 8
SYS1 Sys1 golgi trafficking protein
SYT12 synaptotagmin XII
TAS2R16 taste receptor, type 2, member 16
TBC1D23 TBC1 domain family, member 23
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein
TGFBI transforming growth factor, beta-induced, 68kDa
TGOLN2 trans-golgi network protein 2
TJAP1 tight junction associated protein 1 (peripheral)
TMEM165 transmembrane protein 165
TMEM230 transmembrane protein 230
TMEM79 transmembrane protein 79
TRAPPC6A trafficking protein particle complex 6A
TRAPPC6B trafficking protein particle complex 6B
TRAPPC9 trafficking protein particle complex 9
USP6NL USP6 N-terminal like
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP3 vesicle-associated membrane protein 3
VAMP4 vesicle-associated membrane protein 4
VAMP7 vesicle-associated membrane protein 7
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VTI1A vesicle transport through interaction with t-SNAREs 1A
WDR11 WD repeat domain 11
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YIPF1 Yip1 domain family, member 1
YIPF2 Yip1 domain family, member 2
YIPF4 Yip1 domain family, member 4
YIPF5 Yip1 domain family, member 5
YIPF6 Yip1 domain family, member 6
YIPF7 Yip1 domain family, member 7