transforming growth factor beta receptor signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0007179)
External Link http://amigo.geneontology.org/amigo/term/GO:0007179
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Genes

77 genes participating in the transforming growth factor beta receptor signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVRL1 activin A receptor type II-like 1
ADAM9 ADAM metallopeptidase domain 9
APOA1 apolipoprotein A-I
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARRB2 arrestin, beta 2
BAMBI BMP and activin membrane-bound inhibitor
BMPR1A bone morphogenetic protein receptor, type IA
CDH5 cadherin 5, type 2 (vascular endothelium)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLDN5 claudin 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP22 dual specificity phosphatase 22
EID2 EP300 interacting inhibitor of differentiation 2
ENG endoglin
FERMT2 fermitin family member 2
FMOD fibromodulin
FNTA farnesyltransferase, CAAX box, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXH1 forkhead box H1
FSHB follicle stimulating hormone, beta polypeptide
FURIN furin (paired basic amino acid cleaving enzyme)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDF10 growth differentiation factor 10
GDF15 growth differentiation factor 15
GDF5 growth differentiation factor 5
GDF9 growth differentiation factor 9
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB5 integrin, beta 5
JUN jun proto-oncogene
LEFTY1 left-right determination factor 1
LPXN leupaxin
LRG1 leucine-rich alpha-2-glycoprotein 1
LRRC32 leucine rich repeat containing 32
LTBP3 latent transforming growth factor beta binding protein 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
NLK nemo-like kinase
NRROS negative regulator of reactive oxygen species
PIAS2 protein inhibitor of activated STAT, 2
PSG9 pregnancy specific beta-1-glycoprotein 9
PTK2 protein tyrosine kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
PXDN peroxidasin
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGFBR3L transforming growth factor, beta receptor III-like
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TSKU tsukushi, small leucine rich proteoglycan
USP15 ubiquitin specific peptidase 15
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ1 zinc finger, MIZ-type containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZYX zyxin