translation initiation complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. (Gene Ontology, GO_0070992)
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88 proteins co-occuring with the translation initiation complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
EIF4E eukaryotic translation initiation factor 4E 2.11585
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 1.84634
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.43387
EIF4E2 eukaryotic translation initiation factor 4E family member 2 1.23452
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.19931
PABPC1 poly(A) binding protein, cytoplasmic 1 1.10562
NCBP2 nuclear cap binding protein subunit 2, 20kDa 1.05791
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.02331
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.993672
EIF1 eukaryotic translation initiation factor 1 0.930304
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.919514
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.883782
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.883321
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.824959
EIF4A3 eukaryotic translation initiation factor 4A3 0.8245
CTIF CBP80/20-dependent translation initiation factor 0.82037
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.786444
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.779583
RALY RALY heterogeneous nuclear ribonucleoprotein 0.775014
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.760887
METAP2 methionyl aminopeptidase 2 0.734666
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.703949
EIF4B eukaryotic translation initiation factor 4B 0.664232
MIF4GD MIF4G domain containing 0.627335
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.582176
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.568001
PAIP2 poly(A) binding protein interacting protein 2 0.563847
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.54936
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.54936
EIF4A1 eukaryotic translation initiation factor 4A1 0.544823
EIF3K eukaryotic translation initiation factor 3, subunit K 0.544411
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.541529
NGDN neuroguidin, EIF4E binding protein 0.538238
EIF3C eukaryotic translation initiation factor 3, subunit C 0.530847
RPS25 ribosomal protein S25 0.530438
EIF3F eukaryotic translation initiation factor 3, subunit F 0.51694
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 0.487307
RBM14 RNA binding motif protein 14 0.48287
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.480855
RBM4 RNA binding motif protein 4 0.473617
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.454019
METAP1 methionyl aminopeptidase 1 0.449245
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.436565
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.427497
RPS6 ribosomal protein S6 0.407529
EIF5B eukaryotic translation initiation factor 5B 0.405971
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.403248
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.398975
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.395873
BMF Bcl2 modifying factor 0.381584
PDX1 pancreatic and duodenal homeobox 1 0.378891
DRD3 dopamine receptor D3 0.373516
CCL5 chemokine (C-C motif) ligand 5 0.360515
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.341529
CCND1 cyclin D1 0.340773
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.329461
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.324201
ABHD14A abhydrolase domain containing 14A 0.320826
DAD1 defender against cell death 1 0.318205
HIP1R huntingtin interacting protein 1 related 0.314839
PER3 period circadian clock 3 0.311478
DUSP6 dual specificity phosphatase 6 0.277774
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.269701
PKP1 plakophilin 1 0.267139
TIMELESS timeless circadian clock 0.260931
SYNJ1 synaptojanin 1 0.259837
GCH1 GTP cyclohydrolase 1 0.246769
WFS1 Wolfram syndrome 1 (wolframin) 0.24424
GLI3 GLI family zinc finger 3 0.235249
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.233101
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.231315
CGB7 chorionic gonadotropin, beta polypeptide 7 0.21646
CGB5 chorionic gonadotropin, beta polypeptide 5 0.21646
EIF5 eukaryotic translation initiation factor 5 0.211933
CGB chorionic gonadotropin, beta polypeptide 0.208481
CGB8 chorionic gonadotropin, beta polypeptide 8 0.206766
SUMO1 small ubiquitin-like modifier 1 0.196339
DPYSL2 dihydropyrimidinase-like 2 0.192746
AGO1 argonaute RISC catalytic component 1 0.188905
VEGFA vascular endothelial growth factor A 0.185777
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.183631
STAU1 staufen double-stranded RNA binding protein 1 0.170629
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.170371
SNORA29 small nucleolar RNA, H/ACA box 29 0.166167
RGS4 regulator of G-protein signaling 4 0.165231
SMAD5 SMAD family member 5 0.164315
CLOCK clock circadian regulator 0.161905
UBE3A ubiquitin protein ligase E3A 0.161693