transmembrane receptor protein tyrosine kinase signaling pathway Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. (Gene Ontology, GO_0007169)
External Link http://amigo.geneontology.org/amigo/term/GO_0007169
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Genes

285 genes participating in the transmembrane receptor protein tyrosine kinase signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ABI1 abl-interactor 1
ADRB2 adrenoceptor beta 2, surface
AHI1 Abelson helper integration site 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL1 angiopoietin-like 1
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
AXL AXL receptor tyrosine kinase
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CAV2 caveolin 2
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD7 CD7 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP57 centrosomal protein 57kDa
CHN1 chimerin 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHURC1 churchill domain containing 1
CLNK cytokine-dependent hematopoietic cell linker
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL4A2 collagen, type IV, alpha 2
COL4A6 collagen, type IV, alpha 6
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CSHL1 chorionic somatomammotropin hormone-like 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DDR2 discoidin domain receptor tyrosine kinase 2
DEAR dual endothelin-1(VEGFsp)/angiotensin II receptor pseudogene
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
DOK4 docking protein 4
DOK5 docking protein 5
DOK6 docking protein 6
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA5 ephrin-A5
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPHA1 EPH receptor A1
EPHA10 EPH receptor A10
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
EPHA5 EPH receptor A5
EPHA6 EPH receptor A6
EPHA7 EPH receptor A7
EPHA8 EPH receptor A8
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM150A family with sequence similarity 150, member A
FAM150B family with sequence similarity 150, member B
FER fer (fps/fes related) tyrosine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGR FGR proto-oncogene, Src family tyrosine kinase
FIBP fibroblast growth factor (acidic) intracellular binding protein
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLRT1 fibronectin leucine rich transmembrane protein 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOXC1 forkhead box C1
FOXC2 forkhead box C2
FOXO1 forkhead box O1
FOXO4 forkhead box O4
FRK fyn-related Src family tyrosine kinase
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF15 growth differentiation factor 15
GFRA2 GDNF family receptor alpha 2
GFRAL GDNF family receptor alpha like
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL31RA interleukin 31 receptor A
INS insulin
INSR insulin receptor
INSRR insulin receptor-related receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK2 Janus kinase 2
KALRN kalirin, RhoGEF kinase
KDR kinase insert domain receptor
KIF16B kinesin family member 16B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LTK leukocyte receptor tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPZL1 myelin protein zero-like 1
MST1R macrophage stimulating 1 receptor
MTSS1 metastasis suppressor 1
MUC20 mucin 20, cell surface associated
MUSK muscle, skeletal, receptor tyrosine kinase
MVP major vault protein
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL1 NEL-like 1 (chicken)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NGEF neuronal guanine nucleotide exchange factor
NGF nerve growth factor (beta polypeptide)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGF placental growth factor
PHIP pleckstrin homology domain interacting protein
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PILRB paired immunoglobin-like type 2 receptor beta
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLR1G RNA polymerase I subunit G
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRLR prolactin receptor
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRT protein tyrosine phosphatase, receptor type, T
PXN paxillin
RAB14 RAB14, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRP4 RAS guanyl releasing protein 4
RET ret proto-oncogene
RGS14 regulator of G-protein signaling 14
RHOQ ras homolog family member Q
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RYK receptor-like tyrosine kinase
SAMD10 sterile alpha motif domain containing 10
SAMD12 sterile alpha motif domain containing 12
SETX senataxin
SH2B2 SH2B adaptor protein 2
SH2D6 SH2 domain containing 6
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SHCBP1 SHC SH2-domain binding protein 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOCS2 suppressor of cytokine signaling 2
SOGA1 suppressor of glucose, autophagy associated 1
SORBS1 sorbin and SH3 domain containing 1
SORT1 sortilin 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
STXBP4 syntaxin binding protein 4
SULF1 sulfatase 1
SULF2 sulfatase 2
SYK spleen tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TIAM1 T-cell lymphoma invasion and metastasis 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TSC2 tuberous sclerosis 2
TYRO3 TYRO3 protein tyrosine kinase
UBASH3B ubiquitin associated and SH3 domain containing B
UXT ubiquitously-expressed, prefoldin-like chaperone
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFYVE27 zinc finger, FYVE domain containing 27
ZNF106 zinc finger protein 106