trapidil-7475 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trapidil-7475 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADORA1 adenosine A1 receptor
AFAP1 actin filament associated protein 1
AGER advanced glycosylation end product-specific receptor
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALDOB aldolase B, fructose-bisphosphate
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOE apolipoprotein E
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL3 ADP-ribosylation factor-like 3
ASTN2 astrotactin 2
AURKA aurora kinase A
BTF3P12 basic transcription factor 3 pseudogene 12
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C2ORF27A chromosome 2 open reading frame 27A
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD44 CD44 molecule (Indian blood group)
CDC14A cell division cycle 14A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDH10 cadherin 10, type 2 (T2-cadherin)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
COL8A2 collagen, type VIII, alpha 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNM1 dynamin 1
DOK2 docking protein 2, 56kDa
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ECE1 endothelin converting enzyme 1
EFNB3 ephrin-B3
ELOVL5 ELOVL fatty acid elongase 5
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERCC2 excision repair cross-complementation group 2
ERN1 endoplasmic reticulum to nucleus signaling 1
EXPH5 exophilin 5
FADS3 fatty acid desaturase 3
FAM65A family with sequence similarity 65, member A
FOXG1 forkhead box G1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GPC3 glypican 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
GSTM4 glutathione S-transferase mu 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HBEGF heparin-binding EGF-like growth factor
HOXC10 homeobox C10
IQCK IQ motif containing K
ITPK1 inositol-tetrakisphosphate 1-kinase
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD17 potassium channel tetramerization domain containing 17
KCTD2 potassium channel tetramerization domain containing 2
KLHL22 kelch-like family member 22
LAMP1 lysosomal-associated membrane protein 1
LOC390998 ribosomal protein L10 pseudogene
MALT1 MALT1 paracaspase
MDM4 MDM4, p53 regulator
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MVP major vault protein
NF2 neurofibromin 2 (merlin)
NUP62CL nucleoporin 62kDa C-terminal like
PCNX pecanex homolog (Drosophila)
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PHF20 PHD finger protein 20
PLXNB1 plexin B1
PLXNB3 plexin B3
POMT2 protein-O-mannosyltransferase 2
PPARD peroxisome proliferator-activated receptor delta
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRDM12 PR domain containing 12
RERE arginine-glutamic acid dipeptide (RE) repeats
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
S100A8 S100 calcium binding protein A8
SFTPB surfactant protein B
SFTPC surfactant protein C
SIRT3 sirtuin 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SPHK2 sphingosine kinase 2
TAPBP TAP binding protein (tapasin)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRABD TraB domain containing
TREX1 three prime repair exonuclease 1
TRIM25 tripartite motif containing 25
TRIP11 thyroid hormone receptor interactor 11
TSC22D4 TSC22 domain family, member 4
TTC9 tetratricopeptide repeat domain 9
VASH2 vasohibin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR25 WD repeat domain 25
ZBTB22 zinc finger and BTB domain containing 22
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACVR2A activin A receptor, type IIA
AES amino-terminal enhancer of split
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATF3 activating transcription factor 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAGE B melanoma antigen
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BPGM 2,3-bisphosphoglycerate mutase
C5 complement component 5
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CENPQ centromere protein Q
CFD complement factor D (adipsin)
CGREF1 cell growth regulator with EF-hand domain 1
CHKB choline kinase beta
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLK1 CDC-like kinase 1
CPTP ceramide-1-phosphate transfer protein
DCAF13 DDB1 and CUL4 associated factor 13
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DVL1 dishevelled segment polarity protein 1
EVPL envoplakin
FAM160B2 family with sequence similarity 160, member B2
FBXO46 F-box protein 46
FKBP10 FK506 binding protein 10, 65 kDa
FKBPL FK506 binding protein like
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
GRB7 growth factor receptor-bound protein 7
HDAC11 histone deacetylase 11
HDAC4 histone deacetylase 4
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H4F histone cluster 1, H4f
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HPS6 Hermansky-Pudlak syndrome 6
IL10RB interleukin 10 receptor, beta
IL4R interleukin 4 receptor
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC49 leucine rich repeat containing 49
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MYO9A myosin IXA
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NT5C 5', 3'-nucleotidase, cytosolic
NUBPL nucleotide binding protein-like
PCSK7 proprotein convertase subtilisin/kexin type 7
PGR progesterone receptor
PODXL podocalyxin-like
PROS1 protein S (alpha)
RAB4B RAB4B, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SIK1 salt-inducible kinase 1
SLC25A40 solute carrier family 25, member 40
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STBD1 starch binding domain 1
SUSD4 sushi domain containing 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TTC30A tetratricopeptide repeat domain 30A
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
WDR62 WD repeat domain 62
XYLT2 xylosyltransferase II
ZNF16 zinc finger protein 16
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNF516 zinc finger protein 516
ZNF574 zinc finger protein 574
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668
ZNF813 zinc finger protein 813
ZNHIT2 zinc finger, HIT-type containing 2