tretinoin-224 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tretinoin-224 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ACAA2 acetyl-CoA acyltransferase 2
ACACA acetyl-CoA carboxylase alpha
ADAM20 ADAM metallopeptidase domain 20
ADAP1 ArfGAP with dual PH domains 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADM2 adrenomedullin 2
AKR1C3 aldo-keto reductase family 1, member C3
AKT2 v-akt murine thymoma viral oncogene homolog 2
AQP1 aquaporin 1 (Colton blood group)
BDKRB2 bradykinin receptor B2
BTG2 BTG family, member 2
CCL25 chemokine (C-C motif) ligand 25
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK10 cyclin-dependent kinase 10
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLK1 CDC-like kinase 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DLEC1 deleted in lung and esophageal cancer 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUS2 dihydrouridine synthase 2
EPAS1 endothelial PAS domain protein 1
EPN1 epsin 1
FAM153A family with sequence similarity 153, member A
FAM188A family with sequence similarity 188, member A
FNDC3A fibronectin type III domain containing 3A
FOXC1 forkhead box C1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPR173 G protein-coupled receptor 173
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HMX1 H6 family homeobox 1
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB7 homeobox B7
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFFO1 intermediate filament family orphan 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRS2 insulin receptor substrate 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0125 KIAA0125
KIAA0391 KIAA0391
LAMA3 laminin, alpha 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100127972 uncharacterized LOC100127972
LUZP1 leucine zipper protein 1
MCOLN3 mucolipin 3
MEF2D myocyte enhancer factor 2D
METTL18 methyltransferase like 18
MINK1 misshapen-like kinase 1
MOB3B MOB kinase activator 3B
MYL10 myosin, light chain 10, regulatory
MYO1F myosin IF
NPAS2 neuronal PAS domain protein 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PAIP2B poly(A) binding protein interacting protein 2B
PAX1 paired box 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNB1 plexin B1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRB1 proline-rich protein BstNI subfamily 1
RBPMS RNA binding protein with multiple splicing
RNASE3 ribonuclease, RNase A family, 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SKAP2 src kinase associated phosphoprotein 2
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
STK11 serine/threonine kinase 11
STRA6 stimulated by retinoic acid 6
TAGLN transgelin
TBX3 T-box 3
TCEA2 transcription elongation factor A (SII), 2
TFPI2 tissue factor pathway inhibitor 2
TGM5 transglutaminase 5
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TRAK1 trafficking protein, kinesin binding 1
TRIL TLR4 interactor with leucine-rich repeats
TRIM2 tripartite motif containing 2
TRIM31 tripartite motif containing 31
TRPV5 transient receptor potential cation channel, subfamily V, member 5
USP20 ubiquitin specific peptidase 20
WDR1 WD repeat domain 1
WDR18 WD repeat domain 18
WNT7A wingless-type MMTV integration site family, member 7A
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMN amnion associated transmembrane protein
ANXA1 annexin A1
ASCC2 activating signal cointegrator 1 complex subunit 2
ASIP agouti signaling protein
C11ORF80 chromosome 11 open reading frame 80
C16ORF59 chromosome 16 open reading frame 59
C17ORF80 chromosome 17 open reading frame 80
C1QB complement component 1, q subcomponent, B chain
CBX2 chromobox homolog 2
CD101 CD101 molecule
CEP112 centrosomal protein 112kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCF1 cardiotrophin-like cytokine factor 1
CLCN6 chloride channel, voltage-sensitive 6
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
CRTAC1 cartilage acidic protein 1
CST8 cystatin 8 (cystatin-related epididymal specific)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DCAF16 DDB1 and CUL4 associated factor 16
DCSTAMP dendrocyte expressed seven transmembrane protein
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DRP2 dystrophin related protein 2
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNA3 ephrin-A3
EGR3 early growth response 3
ERO1L ERO1-like (S. cerevisiae)
FAM76A family with sequence similarity 76, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGF22 fibroblast growth factor 22
FGFBP1 fibroblast growth factor binding protein 1
FOXF1 forkhead box F1
FXYD1 FXYD domain containing ion transport regulator 1
FZD4 frizzled class receptor 4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GRIP2 glutamate receptor interacting protein 2
H2AFY2 H2A histone family, member Y2
HCG4B HLA complex group 4B (non-protein coding)
HOXD11 homeobox D11
HSPB3 heat shock 27kDa protein 3
JAM3 junctional adhesion molecule 3
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
LGALS13 lectin, galactoside-binding, soluble, 13
LHX6 LIM homeobox 6
LMTK1 lemur tail kinase 1
LOC100286895 cell division cycle 27 homolog pseudogene
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARC1 mitochondrial amidoxime reducing component 1
MARK1 MAP/microtubule affinity-regulating kinase 1
MGC2889 uncharacterized protein MGC2889
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCKAP1L NCK-associated protein 1-like
NOS2 nitric oxide synthase 2, inducible
OVOL1 ovo-like zinc finger 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCOLCE procollagen C-endopeptidase enhancer
PLVAP plasmalemma vesicle associated protein
POU5F1B POU class 5 homeobox 1B
PRAMEF12 PRAME family member 12
PRSS53 protease, serine, 53
PSG2 pregnancy specific beta-1-glycoprotein 2
PTK7 protein tyrosine kinase 7 (inactive)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RPS2P45 ribosomal protein S2 pseudogene 45
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIL1 SIL1 nucleotide exchange factor
SIRT2 sirtuin 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A16 solute carrier family 6, member 16
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMO smoothened, frizzled class receptor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TET3 tet methylcytosine dioxygenase 3
VIPR1 vasoactive intestinal peptide receptor 1
WNT3 wingless-type MMTV integration site family, member 3
ZBTB22 zinc finger and BTB domain containing 22
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36 ZFP36 ring finger protein
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF23 zinc finger protein 23
ZNF32 zinc finger protein 32
ZNF446 zinc finger protein 446
ZNF668 zinc finger protein 668