tretinoin-6243 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the tretinoin-6243 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM8 ADAM metallopeptidase domain 8
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BDKRB2 bradykinin receptor B2
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCKAR cholecystokinin A receptor
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRELD1 cysteine-rich with EGF-like domains 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY2 cryptochrome circadian clock 2
CRYGC crystallin, gamma C
CSF1R colony stimulating factor 1 receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DESI2 desumoylating isopeptidase 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DRD1 dopamine receptor D1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM174B family with sequence similarity 174, member B
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXC13 homeobox C13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INADL InaD-like (Drosophila)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KLHL29 kelch-like family member 29
L3MBTL1 l(3)mbt-like 1 (Drosophila)
MAP2K7 mitogen-activated protein kinase kinase 7
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MEG3 maternally expressed 3 (non-protein coding)
MOCS1 molybdenum cofactor synthesis 1
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
OPN3 opsin 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBX2 pre-B-cell leukemia homeobox 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLA2G10 phospholipase A2, group X
PRKCD protein kinase C, delta
PRMT2IP PRMT2 interacting protein
PRSS50 protease, serine, 50
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
RAP1GAP RAP1 GTPase activating protein
RGS16 regulator of G-protein signaling 16
RPLP2 ribosomal protein, large, P2
RTEL1 regulator of telomere elongation helicase 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SETD8 SET domain containing (lysine methyltransferase) 8
SIK1 salt-inducible kinase 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
STAB2 stabilin 2
STRA6 stimulated by retinoic acid 6
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAK1 trafficking protein, kinesin binding 1
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
USB1 U6 snRNA biogenesis 1
VCL vinculin
WDR62 WD repeat domain 62

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGR2 anterior gradient 2
APH1B APH1B gamma secretase subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C16ORF45 chromosome 16 open reading frame 45
C17ORF80 chromosome 17 open reading frame 80
C1ORF115 chromosome 1 open reading frame 115
C1ORF27 chromosome 1 open reading frame 27
C21ORF91 chromosome 21 open reading frame 91
C3ORF52 chromosome 3 open reading frame 52
C5 complement component 5
CA2 carbonic anhydrase II
CAMTA1 calmodulin binding transcription activator 1
CAPN15 calpain 15
CCDC15 coiled-coil domain containing 15
CFD complement factor D (adipsin)
CHMP7 charged multivesicular body protein 7
CLK4 CDC-like kinase 4
COBL cordon-bleu WH2 repeat protein
CROT carnitine O-octanoyltransferase
CXORF56 chromosome X open reading frame 56
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMBP dynamin binding protein
ECHDC3 enoyl CoA hydratase domain containing 3
EGR3 early growth response 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPN3 epsin 3
ERO1L ERO1-like (S. cerevisiae)
EVPL envoplakin
FAM188A family with sequence similarity 188, member A
FAM64A family with sequence similarity 64, member A
FBXW12 F-box and WD repeat domain containing 12
FKBP5 FK506 binding protein 5
GAS8 growth arrest-specific 8
GNA12 guanine nucleotide binding protein (G protein) alpha 12
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2AC histone cluster 1, H2ac
HMHA1 histocompatibility (minor) HA-1
HOOK1 hook microtubule-tethering protein 1
HOXC6 homeobox C6
IGSF3 immunoglobulin superfamily, member 3
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KCTD15 potassium channel tetramerization domain containing 15
KIF14 kinesin family member 14
KLHL36 kelch-like family member 36
LIN37 lin-37 DREAM MuvB core complex component
LMNB1 lamin B1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC37A2 leucine rich repeat containing 37, member A2
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MAP9 microtubule-associated protein 9
METTL16 methyltransferase like 16
MFSD12 major facilitator superfamily domain containing 12
MINPP1 multiple inositol-polyphosphate phosphatase 1
MRPL2 mitochondrial ribosomal protein L2
MT1HL1 metallothionein 1H-like 1
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NDC80 NDC80 kinetochore complex component
NR1D2 nuclear receptor subfamily 1, group D, member 2
OXTR oxytocin receptor
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PARD6A par-6 family cell polarity regulator alpha
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLEKHA5 pleckstrin homology domain containing, family A member 5
PODXL podocalyxin-like
PYGB phosphorylase, glycogen; brain
RAB8B RAB8B, member RAS oncogene family
RHOB ras homolog family member B
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RWDD2A RWD domain containing 2A
SALL2 spalt-like transcription factor 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMAD7 SMAD family member 7
SPIN1 spindlin 1
SSBP2 single-stranded DNA binding protein 2
STK16 serine/threonine kinase 16
TESK2 testis-specific kinase 2
TMEM168 transmembrane protein 168
TPST2 tyrosylprotein sulfotransferase 2
TRPS1 trichorhinophalangeal syndrome I
VAV3 vav 3 guanine nucleotide exchange factor
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586
ZXDC ZXD family zinc finger C