tretinoin-6931 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tretinoin-6931 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT4 angiopoietin 4
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AQP3 aquaporin 3 (Gill blood group)
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
BTD biotinidase
BTG2 BTG family, member 2
C1ORF112 chromosome 1 open reading frame 112
C2ORF54 chromosome 2 open reading frame 54
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDH5 cadherin 5, type 2 (vascular endothelium)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLMN calmin (calponin-like, transmembrane)
CNR2 cannabinoid receptor 2 (macrophage)
CSTA cystatin A (stefin A)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DALRD3 DALR anticodon binding domain containing 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIEXF digestive organ expansion factor homolog (zebrafish)
DUSP4 dual specificity phosphatase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM174B family with sequence similarity 174, member B
FZD5 frizzled class receptor 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP2 guanylate binding protein 2, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GID4 GID complex subunit 4
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H4D histone cluster 1, H4d
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXC10 homeobox C10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KAZN kazrin, periplakin interacting protein
KIAA0125 KIAA0125
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR4 lysophosphatidic acid receptor 4
LPPR2 lipid phosphate phosphatase-related protein type 2
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MBNL3 muscleblind-like splicing regulator 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MID1IP1 MID1 interacting protein 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYOF myoferlin
NANS N-acetylneuraminic acid synthase
NAV2 neuron navigator 2
NBEAL2 neurobeachin-like 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G10 phospholipase A2, group X
PLA2G1B phospholipase A2, group IB (pancreas)
PRKCD protein kinase C, delta
PRR5 proline rich 5 (renal)
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
ROM1 retinal outer segment membrane protein 1
SCAMP1 secretory carrier membrane protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIK1 salt-inducible kinase 1
SIX1 SIX homeobox 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TLE4 transducin-like enhancer of split 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRAK1 trafficking protein, kinesin binding 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
XYLT1 xylosyltransferase I
YLPM1 YLP motif containing 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
AHDC1 AT hook, DNA binding motif, containing 1
AKTIP AKT interacting protein
ANKRD36B ankyrin repeat domain 36B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGAP5 Rho GTPase activating protein 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
C3ORF52 chromosome 3 open reading frame 52
CCNL2 cyclin L2
CD320 CD320 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN9 claudin 9
CLIC3 chloride intracellular channel 3
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSK cathepsin K
DMTF1 cyclin D binding myb-like transcription factor 1
EGR3 early growth response 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM114A1 family with sequence similarity 114, member A1
FAM188A family with sequence similarity 188, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO46 F-box protein 46
FEM1C fem-1 homolog c (C. elegans)
FIP1L1 factor interacting with PAPOLA and CPSF1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GCHFR GTP cyclohydrolase I feedback regulator
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRAMD3 GRAM domain containing 3
H2AFJ H2A histone family, member J
HPS5 Hermansky-Pudlak syndrome 5
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGSF3 immunoglobulin superfamily, member 3
IRX4 iroquois homeobox 4
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM5C lysine (K)-specific demethylase 5C
KIAA0895 KIAA0895
LIN37 lin-37 DREAM MuvB core complex component
MAMLD1 mastermind-like domain containing 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP7D1 MAP7 domain containing 1
MBD5 methyl-CpG binding domain protein 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MORC3 MORC family CW-type zinc finger 3
MOSPD3 motile sperm domain containing 3
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTERF1 mitochondrial transcription termination factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPY1R neuropeptide Y receptor Y1
NT5C 5', 3'-nucleotidase, cytosolic
PIAS3 protein inhibitor of activated STAT, 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMM1 phosphomannomutase 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R26 protein phosphatase 1, regulatory subunit 26
PRODH proline dehydrogenase (oxidase) 1
PTDSS2 phosphatidylserine synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB4B RAB4B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF170 ring finger protein 170
SERTAD3 SERTA domain containing 3
SFXN3 sideroflexin 3
SHROOM2 shroom family member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SNX16 sorting nexin 16
SOX3 SRY (sex determining region Y)-box 3
SSBP2 single-stranded DNA binding protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN1 tectonic family member 1
TM7SF3 transmembrane 7 superfamily member 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNNT1 troponin T type 1 (skeletal, slow)
TPST2 tyrosylprotein sulfotransferase 2
TRAF5 TNF receptor-associated factor 5
TRIM32 tripartite motif containing 32
TRIM45 tripartite motif containing 45
TUBA3D tubulin, alpha 3d
UBE2S ubiquitin-conjugating enzyme E2S
UBQLN4 ubiquilin 4
VASH2 vasohibin 2
VAV3 vav 3 guanine nucleotide exchange factor
WDR19 WD repeat domain 19
XYLT2 xylosyltransferase II
ZFP36 ZFP36 ring finger protein
ZNF253 zinc finger protein 253
ZNF254 zinc finger protein 254
ZNF268 zinc finger protein 268
ZNF33B zinc finger protein 33B
ZNF468 zinc finger protein 468
ZNF85 zinc finger protein 85