tretinoin-6971 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tretinoin-6971 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMPH amphiphysin
AOAH acyloxyacyl hydrolase (neutrophil)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
BTG2 BTG family, member 2
C7ORF43 chromosome 7 open reading frame 43
CDH5 cadherin 5, type 2 (vascular endothelium)
CLMN calmin (calponin-like, transmembrane)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCLK2 doublecortin-like kinase 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLK2 delta-like 2 homolog (Drosophila)
DLX2 distal-less homeobox 2
EFNA3 ephrin-A3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAM105A family with sequence similarity 105, member A
FAM174B family with sequence similarity 174, member B
FBRS fibrosin
FGF4 fibroblast growth factor 4
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HCAR3 hydroxycarboxylic acid receptor 3
HOXA1 homeobox A1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXC10 homeobox C10
HOXC13 homeobox C13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGHA1 immunoglobulin heavy constant alpha 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IRF1 interferon regulatory factor 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0125 KIAA0125
KLK6 kallikrein-related peptidase 6
KRT15 keratin 15, type I
LONP2 lon peptidase 2, peroxisomal
MAP4 microtubule-associated protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NACA2 nascent polypeptide-associated complex alpha subunit 2
NANS N-acetylneuraminic acid synthase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G10 phospholipase A2, group X
PRKCD protein kinase C, delta
PRR5 proline rich 5 (renal)
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB11B RAB11B, member RAS oncogene family
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
ROM1 retinal outer segment membrane protein 1
RPLP2 ribosomal protein, large, P2
SAP30 Sin3A-associated protein, 30kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SIGLEC15 sialic acid binding Ig-like lectin 15
SIK1 salt-inducible kinase 1
SIRT3 sirtuin 3
SIX1 SIX homeobox 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOX9 SRY (sex determining region Y)-box 9
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
TCP11L1 t-complex 11, testis-specific-like 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM31 tripartite motif containing 31
TSC22D3 TSC22 domain family, member 3
TUBA3C tubulin, alpha 3c
ZHX3 zinc fingers and homeoboxes 3
ZNF16 zinc finger protein 16
ZNF419 zinc finger protein 419
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AGBL5 ATP/GTP binding protein-like 5
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANKRD36B ankyrin repeat domain 36B
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATAD3A ATPase family, AAA domain containing 3A
C10ORF88 chromosome 10 open reading frame 88
C16ORF59 chromosome 16 open reading frame 59
C17ORF62 chromosome 17 open reading frame 62
C1ORF115 chromosome 1 open reading frame 115
C1ORF56 chromosome 1 open reading frame 56
C3ORF52 chromosome 3 open reading frame 52
CALHM2 calcium homeostasis modulator 2
CCDC15 coiled-coil domain containing 15
CCDC25 coiled-coil domain containing 25
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGREF1 cell growth regulator with EF-hand domain 1
CISH cytokine inducible SH2-containing protein
CLSPN claspin
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAL4 dynein, axonemal, light chain 4
EFHD1 EF-hand domain family, member D1
EGR3 early growth response 3
FAM192A family with sequence similarity 192, member A
FAM222B family with sequence similarity 222, member B
FKBP10 FK506 binding protein 10, 65 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GHR growth hormone receptor
GMIP GEM interacting protein
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRAMD3 GRAM domain containing 3
GSTT1 glutathione S-transferase theta 1
H2AFY2 H2A histone family, member Y2
HS1BP3 HCLS1 binding protein 3
IGSF3 immunoglobulin superfamily, member 3
IRF2 interferon regulatory factor 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0556 KIAA0556
KLHL12 kelch-like family member 12
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LINC00115 long intergenic non-protein coding RNA 115
LOC100287590 uncharacterized LOC100287590
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEF1 melanoma antigen family F1
MAMLD1 mastermind-like domain containing 1
MARC1 mitochondrial amidoxime reducing component 1
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXD3 MAX dimerization protein 3
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYLIP myosin regulatory light chain interacting protein
NADSYN1 NAD synthetase 1
NES nestin
NPY1R neuropeptide Y receptor Y1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NXN nucleoredoxin
OGFRL1 opioid growth factor receptor-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAQR4 progestin and adipoQ receptor family member IV
PCF11 PCF11 cleavage and polyadenylation factor subunit
PMM1 phosphomannomutase 1
PMP22 peripheral myelin protein 22
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM41 RNA binding motif protein 41
RECQL4 RecQ protein-like 4
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCAMP4 secretory carrier membrane protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SHARPIN SHANK-associated RH domain interactor
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC25A40 solute carrier family 25, member 40
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPIDR scaffolding protein involved in DNA repair
STAG3 stromal antigen 3
STX5 syntaxin 5
THAP7 THAP domain containing 7
TMEM8A transmembrane protein 8A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPS1 trichorhinophalangeal syndrome I
TULP4 tubby like protein 4
UBQLN4 ubiquilin 4
XYLT2 xylosyltransferase II
ZFP30 ZFP30 zinc finger protein
ZNF14 zinc finger protein 14
ZNF143 zinc finger protein 143
ZNF408 zinc finger protein 408
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668