tricarboxylic acid cycle Gene Set

Dataset GO Biological Process Annotations 2015
Category structural or functional annotations
Type biological process
Description A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. (Gene Ontology, GO_0006099)
External Link http://amigo.geneontology.org/amigo/term/GO:0006099
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Genes

29 genes participating in the tricarboxylic acid cycle biological process from the curated GO Biological Process Annotations 2015 dataset.

Symbol Name
ACO1 aconitase 1, soluble
ACO2 aconitase 2, mitochondrial
CS citrate synthase
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DLAT dihydrolipoamide S-acetyltransferase
DLD dihydrolipoamide dehydrogenase
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
FH fumarate hydratase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
MDH1 malate dehydrogenase 1, NAD (soluble)
MDH1B malate dehydrogenase 1B, NAD (soluble)
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
NNT nicotinamide nucleotide transhydrogenase
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OGDHL oxoglutarate dehydrogenase-like
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDHB pyruvate dehydrogenase (lipoamide) beta
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUCLG1 succinate-CoA ligase, alpha subunit
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit