trichlormethiazide-4783 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the trichlormethiazide-4783 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGFG2 ArfGAP with FG repeats 2
ALOX15 arachidonate 15-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ATM ATM serine/threonine kinase
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATRX alpha thalassemia/mental retardation syndrome X-linked
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C2ORF27A chromosome 2 open reading frame 27A
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN9 calpain 9
CD58 CD58 molecule
CD86 CD86 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTRC chymotrypsin C (caldecrin)
CYHR1 cysteine/histidine-rich 1
DEPDC5 DEP domain containing 5
EXOSC1 exosome component 1
FGF17 fibroblast growth factor 17
FGF6 fibroblast growth factor 6
FH fumarate hydratase
FNTB farnesyltransferase, CAAX box, beta
FRMD4B FERM domain containing 4B
FZD9 frizzled class receptor 9
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GIMAP6 GTPase, IMAP family member 6
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GRM8 glutamate receptor, metabotropic 8
GUSBP3 glucuronidase, beta pseudogene 3
HMGN5 high mobility group nucleosome binding domain 5
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGLJ3 immunoglobulin lambda joining 3
ITGA10 integrin, alpha 10
KAT8 K(lysine) acetyltransferase 8
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
LINC00260 long intergenic non-protein coding RNA 260
LMNA lamin A/C
LMOD1 leiomodin 1 (smooth muscle)
LOC440895 two pore channel 3 pseudogene
LPAR3 lysophosphatidic acid receptor 3
LPCAT3 lysophosphatidylcholine acyltransferase 3
LRRC37A3 leucine rich repeat containing 37, member A3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP2K5 mitogen-activated protein kinase kinase 5
MED20 mediator complex subunit 20
MUC1 mucin 1, cell surface associated
NKX2-8 NK2 homeobox 8
NPPA natriuretic peptide A
NRIP3 nuclear receptor interacting protein 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAPPA2 pappalysin 2
PAX5 paired box 5
PCDHGA1 protocadherin gamma subfamily A, 1
PICALM phosphatidylinositol binding clathrin assembly protein
PKD2L2 polycystic kidney disease 2-like 2
PKNOX2 PBX/knotted 1 homeobox 2
PODNL1 podocan-like 1
PRKCH protein kinase C, eta
PRSS3 protease, serine, 3
PTBP3 polypyrimidine tract binding protein 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB33A RAB33A, member RAS oncogene family
RNF122 ring finger protein 122
ROM1 retinal outer segment membrane protein 1
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SENP5 SUMO1/sentrin specific peptidase 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPN sialophorin
SUGP1 SURP and G patch domain containing 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNJ2 synaptojanin 2
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCF20 transcription factor 20 (AR1)
TCP10 t-complex 10
TENM1 teneurin transmembrane protein 1
TGFBR3 transforming growth factor, beta receptor III
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
TUBA4B tubulin, alpha 4b
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VAMP5 vesicle-associated membrane protein 5
VARS valyl-tRNA synthetase
VWA5A von Willebrand factor A domain containing 5A
WDR59 WD repeat domain 59
WIPF1 WAS/WASL interacting protein family, member 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABLIM3 actin binding LIM protein family, member 3
ABT1 activator of basal transcription 1
ADCY6 adenylate cyclase 6
ANKRD36 ankyrin repeat domain 36
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASAP1-IT1 ASAP1 intronic transcript 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BBC3 BCL2 binding component 3
C5AR2 complement component 5a receptor 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIR1 corepressor interacting with RBPJ, 1
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
DOC2A double C2-like domains, alpha
DUSP2 dual specificity phosphatase 2
EGFL7 EGF-like-domain, multiple 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM120C family with sequence similarity 120C
FAM46C family with sequence similarity 46, member C
FBXL2 F-box and leucine-rich repeat protein 2
FKBP10 FK506 binding protein 10, 65 kDa
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45G growth arrest and DNA-damage-inducible, gamma
GLCE glucuronic acid epimerase
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GYS1 glycogen synthase 1 (muscle)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
HSPA1L heat shock 70kDa protein 1-like
IL4R interleukin 4 receptor
IQSEC2 IQ motif and Sec7 domain 2
IRF1 interferon regulatory factor 1
KLHL26 kelch-like family member 26
KLHL36 kelch-like family member 36
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIF leukemia inhibitory factor
LOC100287590 uncharacterized LOC100287590
LRRC8E leucine rich repeat containing 8 family, member E
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MATK megakaryocyte-associated tyrosine kinase
MBNL3 muscleblind-like splicing regulator 3
MITF microphthalmia-associated transcription factor
MNX1 motor neuron and pancreas homeobox 1
MUC3B mucin 3B, cell surface associated
NEO1 neogenin 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NKX3-2 NK3 homeobox 2
PACS1 phosphofurin acidic cluster sorting protein 1
PARPBP PARP1 binding protein
PLXNA3 plexin A3
PNKP polynucleotide kinase 3'-phosphatase
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PRICKLE3 prickle homolog 3 (Drosophila)
PRODH proline dehydrogenase (oxidase) 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHBDD3 rhomboid domain containing 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF121 ring finger protein 121
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL23AP32 ribosomal protein L23a pseudogene 32
SALL2 spalt-like transcription factor 2
SAMD9 sterile alpha motif domain containing 9
SAMHD1 SAM domain and HD domain 1
SDC3 syndecan 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC12A9 solute carrier family 12, member 9
SMA4 glucuronidase, beta pseudogene
SPAG4 sperm associated antigen 4
SREK1IP1 SREK1-interacting protein 1
STEAP4 STEAP family member 4
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TESK1 testis-specific kinase 1
TNRC6B trinucleotide repeat containing 6B
TPRA1 transmembrane protein, adipocyte asscociated 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM5 tripartite motif containing 5
TTBK2 tau tubulin kinase 2
TWF2 twinfilin actin binding protein 2
UBQLN4 ubiquilin 4
USP18 ubiquitin specific peptidase 18
WDR25 WD repeat domain 25
WDR4 WD repeat domain 4
WDR91 WD repeat domain 91
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZFP69B ZFP69 zinc finger protein B
ZNF205 zinc finger protein 205
ZNF408 zinc finger protein 408
ZNF43 zinc finger protein 43
ZNF552 zinc finger protein 552