trichostatin A-1153 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trichostatin A-1153 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD6 ankyrin repeat domain 6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARNT aryl hydrocarbon receptor nuclear translocator
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP10D ATPase, class V, type 10D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRA biliverdin reductase A
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCL20 chemokine (C-C motif) ligand 20
CD59 CD59 molecule, complement regulatory protein
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CREB3 cAMP responsive element binding protein 3
CREM cAMP responsive element modulator
CTSV cathepsin V
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK4 dedicator of cytokinesis 4
EFNA4 ephrin-A4
EPAS1 endothelial PAS domain protein 1
EXTL2 exostosin-like glycosyltransferase 2
F11R F11 receptor
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
FNBP1L formin binding protein 1-like
FUCA1 fucosidase, alpha-L- 1, tissue
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HOXA1 homeobox A1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITGB5 integrin, beta 5
ITSN1 intersectin 1 (SH3 domain protein)
KRCC1 lysine-rich coiled-coil 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAX MYC associated factor X
METTL7A methyltransferase like 7A
MLF1 myeloid leukemia factor 1
MOB3B MOB kinase activator 3B
MPZL1 myelin protein zero-like 1
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH10 myosin, heavy chain 10, non-muscle
MYO1B myosin IB
NCOA1 nuclear receptor coactivator 1
NMRK1 nicotinamide riboside kinase 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PFN2 profilin 2
PHC1 polyhomeotic homolog 1 (Drosophila)
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLS1 plastin 1
POU4F1 POU class 4 homeobox 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SALL2 spalt-like transcription factor 2
SCARB2 scavenger receptor class B, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIDT1 SID1 transmembrane family, member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SP140L SP140 nuclear body protein-like
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPMT thiopurine S-methyltransferase
TRIB2 tribbles pseudokinase 2
TRIM9 tripartite motif containing 9
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UNC119 unc-119 homolog (C. elegans)
WDR19 WD repeat domain 19
WLS wntless Wnt ligand secretion mediator
ZC4H2 zinc finger, C4H2 domain containing
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ANKRD55 ankyrin repeat domain 55
ATAD3A ATPase family, AAA domain containing 3A
BBC3 BCL2 binding component 3
BRIX1 BRX1, biogenesis of ribosomes
C10ORF2 chromosome 10 open reading frame 2
C14ORF159 chromosome 14 open reading frame 159
C16ORF59 chromosome 16 open reading frame 59
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMTA2 calmodulin binding transcription activator 2
CARD9 caspase recruitment domain family, member 9
CCDC86 coiled-coil domain containing 86
CD3EAP CD3e molecule, epsilon associated protein
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLSPN claspin
CLTCL1 clathrin, heavy chain-like 1
CNPY3 canopy FGF signaling regulator 3
CTPS1 CTP synthase 1
CXORF21 chromosome X open reading frame 21
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DPH2 DPH2 homolog (S. cerevisiae)
ENDOG endonuclease G
ERCC2 excision repair cross-complementation group 2
ERF Ets2 repressor factor
FAM136A family with sequence similarity 136, member A
FAM53B family with sequence similarity 53, member B
FXN frataxin
GRWD1 glutamate-rich WD repeat containing 1
HOMER3 homer scaffolding protein 3
HPS6 Hermansky-Pudlak syndrome 6
IFRD2 interferon-related developmental regulator 2
IGSF6 immunoglobulin superfamily, member 6
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
KAT2A K(lysine) acetyltransferase 2A
KCNK5 potassium channel, two pore domain subfamily K, member 5
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LRP3 low density lipoprotein receptor-related protein 3
MACROD1 MACRO domain containing 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MCRS1 microspherule protein 1
METTL1 methyltransferase like 1
MFSD12 major facilitator superfamily domain containing 12
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPDU1 mannose-P-dolichol utilization defect 1
MRPS34 mitochondrial ribosomal protein S34
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOL12 nucleolar protein 12
NOL6 nucleolar protein 6 (RNA-associated)
NR1D2 nuclear receptor subfamily 1, group D, member 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PISD phosphatidylserine decarboxylase
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRMT3 protein arginine methyltransferase 3
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRTN3 proteinase 3
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM15B RNA binding motif protein 15B
RGS19 regulator of G-protein signaling 19
RNF122 ring finger protein 122
RNH1 ribonuclease/angiogenin inhibitor 1
RPAP1 RNA polymerase II associated protein 1
RRP1 ribosomal RNA processing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SDCCAG3 serologically defined colon cancer antigen 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG3 small nucleolar RNA host gene 3
SNORA21 small nucleolar RNA, H/ACA box 21
SNUPN snurportin 1
THOP1 thimet oligopeptidase 1
TMEM209 transmembrane protein 209
TPCN1 two pore segment channel 1
TRABD TraB domain containing
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TTC27 tetratricopeptide repeat domain 27
UBTF upstream binding transcription factor, RNA polymerase I
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WBSCR16 Williams-Beuren syndrome chromosome region 16
WNT10B wingless-type MMTV integration site family, member 10B
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF408 zinc finger protein 408
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF804A zinc finger protein 804A
Funding