trichostatin A-1421 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the trichostatin A-1421 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADD3 adducin 3 (gamma)
ADRBK2 adrenergic, beta, receptor kinase 2
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL3 ADP-ribosylation factor-like 3
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BAG3 BCL2-associated athanogene 3
CCS copper chaperone for superoxide dismutase
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLEC2B C-type lectin domain family 2, member B
CPM carboxypeptidase M
CREB3 cAMP responsive element binding protein 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DSE dermatan sulfate epimerase
DUSP6 dual specificity phosphatase 6
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECI2 enoyl-CoA delta isomerase 2
EFNA4 ephrin-A4
EPAS1 endothelial PAS domain protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
EXPH5 exophilin 5
EXTL2 exostosin-like glycosyltransferase 2
F11R F11 receptor
FAM49A family with sequence similarity 49, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FIG4 FIG4 phosphoinositide 5-phosphatase
FUCA1 fucosidase, alpha-L- 1, tissue
GCH1 GTP cyclohydrolase 1
GLTP glycolipid transfer protein
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPSM2 G-protein signaling modulator 2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOOK2 hook microtubule-tethering protein 2
HRSP12 heat-responsive protein 12
IFI16 interferon, gamma-inducible protein 16
ITGA7 integrin, alpha 7
ITSN1 intersectin 1 (SH3 domain protein)
KHK ketohexokinase (fructokinase)
KIF5C kinesin family member 5C
LHB luteinizing hormone beta polypeptide
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK4 MAP/microtubule affinity-regulating kinase 4
MCOLN1 mucolipin 1
METTL7A methyltransferase like 7A
MPZL1 myelin protein zero-like 1
MTMR3 myotubularin related protein 3
MTSS1 metastasis suppressor 1
N4BP1 NEDD4 binding protein 1
NME7 NME/NM23 family member 7
NQO2 NAD(P)H dehydrogenase, quinone 2
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PIDD1 p53-induced death domain protein 1
PITPNA phosphatidylinositol transfer protein, alpha
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRAF2 PRA1 domain family, member 2
RGS2 regulator of G-protein signaling 2
RHOC ras homolog family member C
RPAP2 RNA polymerase II associated protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
RTN2 reticulon 2
SATB1 SATB homeobox 1
SCAPER S-phase cyclin A-associated protein in the ER
SCML1 sex comb on midleg-like 1 (Drosophila)
SSBP2 single-stranded DNA binding protein 2
STAC SH3 and cysteine rich domain
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TP53BP1 tumor protein p53 binding protein 1
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
TTC13 tetratricopeptide repeat domain 13
TTLL4 tubulin tyrosine ligase-like family member 4
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ASB13 ankyrin repeat and SOCS box containing 13
AZI2 5-azacytidine induced 2
BRIX1 BRX1, biogenesis of ribosomes
C5ORF28 chromosome 5 open reading frame 28
CARD9 caspase recruitment domain family, member 9
CASD1 CAS1 domain containing 1
CASZ1 castor zinc finger 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CLEC5A C-type lectin domain family 5, member A
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNPY3 canopy FGF signaling regulator 3
CTDNEP1 CTD nuclear envelope phosphatase 1
CXORF21 chromosome X open reading frame 21
DCPS decapping enzyme, scavenger
DCTN4 dynactin 4 (p62)
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DKC1 dyskeratosis congenita 1, dyskerin
DTWD1 DTW domain containing 1
ERF Ets2 repressor factor
FAM136A family with sequence similarity 136, member A
FAM216A family with sequence similarity 216, member A
FANCF Fanconi anemia, complementation group F
FES FES proto-oncogene, tyrosine kinase
FMNL1 formin-like 1
FXN frataxin
GPR183 G protein-coupled receptor 183
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HMHA1 histocompatibility (minor) HA-1
HP haptoglobin
IFRD2 interferon-related developmental regulator 2
IMPACT impact RWD domain protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD15 potassium channel tetramerization domain containing 15
KLHL21 kelch-like family member 21
LAMP5 lysosomal-associated membrane protein family, member 5
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LBR lamin B receptor
LMNB1 lamin B1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGOHB mago-nashi homolog B (Drosophila)
MEPCE methylphosphate capping enzyme
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MNT MAX network transcriptional repressor
MORC3 MORC family CW-type zinc finger 3
MPDU1 mannose-P-dolichol utilization defect 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NECAB3 N-terminal EF-hand calcium binding protein 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMI N-myc (and STAT) interactor
NOD1 nucleotide-binding oligomerization domain containing 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PAK1IP1 PAK1 interacting protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PEF1 penta-EF-hand domain containing 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PMF1 polyamine-modulated factor 1
PRMT3 protein arginine methyltransferase 3
PRPF39 pre-mRNA processing factor 39
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
RGS19 regulator of G-protein signaling 19
RNH1 ribonuclease/angiogenin inhibitor 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS14P3 ribosomal protein S14 pseudogene 3
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEH1L SEH1-like (S. cerevisiae)
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNHG3 small nucleolar RNA host gene 3
SPI1 Spi-1 proto-oncogene
ST7 suppression of tumorigenicity 7
STXBP3 syntaxin binding protein 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TOE1 target of EGR1, member 1 (nuclear)
TPRA1 transmembrane protein, adipocyte asscociated 1
TTC27 tetratricopeptide repeat domain 27
UBIAD1 UbiA prenyltransferase domain containing 1
UNG uracil-DNA glycosylase
URGCP upregulator of cell proliferation
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR43 WD repeat domain 43
WDR5B WD repeat domain 5B
XPOT exportin, tRNA
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZEB2 zinc finger E-box binding homeobox 2
ZNF140 zinc finger protein 140
ZNF408 zinc finger protein 408