trichostatin A-1971 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-1971 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AACS acetoacetyl-CoA synthetase
ABI2 abl-interactor 2
AHCYL2 adenosylhomocysteinase-like 2
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BBS1 Bardet-Biedl syndrome 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSDC1 BSD domain containing 1
BTN2A2 butyrophilin, subfamily 2, member A2
CD59 CD59 molecule, complement regulatory protein
CDC25C cell division cycle 25C
CHKA choline kinase alpha
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CPNE3 copine III
CREB3 cAMP responsive element binding protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYLD cylindromatosis (turban tumor syndrome)
DAAM1 dishevelled associated activator of morphogenesis 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECI2 enoyl-CoA delta isomerase 2
EFNA3 ephrin-A3
ELK1 ELK1, member of ETS oncogene family
EML2 echinoderm microtubule associated protein like 2
EPAS1 endothelial PAS domain protein 1
EXTL2 exostosin-like glycosyltransferase 2
F11R F11 receptor
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
FIG4 FIG4 phosphoinositide 5-phosphatase
FUCA1 fucosidase, alpha-L- 1, tissue
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD2 frizzled class receptor 2
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GPR65 G protein-coupled receptor 65
GPSM2 G-protein signaling modulator 2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOXA11 homeobox A11
ICAM2 intercellular adhesion molecule 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
ITGA7 integrin, alpha 7
ITM2C integral membrane protein 2C
ITSN1 intersectin 1 (SH3 domain protein)
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
LINC00094 long intergenic non-protein coding RNA 94
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MGAM maltase-glucoamylase
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MTSS1 metastasis suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NEK1 NIMA-related kinase 1
NEU1 sialidase 1 (lysosomal sialidase)
NME7 NME/NM23 family member 7
NRGN neurogranin (protein kinase C substrate, RC3)
PCGF2 polycomb group ring finger 2
PCNXL2 pecanex-like 2 (Drosophila)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G12A phospholipase A2, group XIIA
PLS1 plastin 1
PRKD2 protein kinase D2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOC ras homolog family member C
RTN2 reticulon 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC2 syndecan 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STXBP1 syntaxin binding protein 1
SUN1 Sad1 and UNC84 domain containing 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPST1 tyrosylprotein sulfotransferase 1
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADI1 acireductone dioxygenase 1
ATF1 activating transcription factor 1
ATXN2 ataxin 2
AURKAIP1 aurora kinase A interacting protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRIX1 BRX1, biogenesis of ribosomes
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CASZ1 castor zinc finger 1
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CIDEB cell death-inducing DFFA-like effector b
CISH cytokine inducible SH2-containing protein
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTPS1 CTP synthase 1
DCPS decapping enzyme, scavenger
DTYMK deoxythymidylate kinase (thymidylate kinase)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERCC2 excision repair cross-complementation group 2
EXOSC10 exosome component 10
FAM136A family with sequence similarity 136, member A
FGR FGR proto-oncogene, Src family tyrosine kinase
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GRAMD4 GRAM domain containing 4
GTPBP6 GTP binding protein 6 (putative)
H2BFS H2B histone family, member S (pseudogene)
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HMHA1 histocompatibility (minor) HA-1
IFRD2 interferon-related developmental regulator 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LYPLA2P1 lysophospholipase II pseudogene 1
MEPCE methylphosphate capping enzyme
MFSD10 major facilitator superfamily domain containing 10
MGMT O-6-methylguanine-DNA methyltransferase
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MRPS28 mitochondrial ribosomal protein S28
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMI N-myc (and STAT) interactor
NUBP2 nucleotide binding protein 2
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUP62 nucleoporin 62kDa
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR4 progestin and adipoQ receptor family member IV
PEF1 penta-EF-hand domain containing 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PMM2 phosphomannomutase 2
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PPAN peter pan homolog (Drosophila)
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRMT3 protein arginine methyltransferase 3
PRTN3 proteinase 3
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN7 protein tyrosine phosphatase, non-receptor type 7
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
REV1 REV1, polymerase (DNA directed)
RGS19 regulator of G-protein signaling 19
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCO2 SCO2 cytochrome c oxidase assembly protein
SECISBP2 SECIS binding protein 2
SFMBT1 Scm-like with four mbt domains 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH3GL1 SH3-domain GRB2-like 1
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SPI1 Spi-1 proto-oncogene
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TFB2M transcription factor B2, mitochondrial
THADA thyroid adenoma associated
THBS4 thrombospondin 4
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMED1 transmembrane emp24 protein transport domain containing 1
TOE1 target of EGR1, member 1 (nuclear)
TTC27 tetratricopeptide repeat domain 27
UBE2O ubiquitin-conjugating enzyme E2O
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN8 UBX domain protein 8
UCK2 uridine-cytidine kinase 2
USP16 ubiquitin specific peptidase 16
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
VWA9 von Willebrand factor A domain containing 9
WT1-AS WT1 antisense RNA
YARS tyrosyl-tRNA synthetase
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
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