trichostatin A-2035 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the trichostatin A-2035 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ACP6 acid phosphatase 6, lysophosphatidic
ADAM8 ADAM metallopeptidase domain 8
AHCYL2 adenosylhomocysteinase-like 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA6 annexin A6
APAF1 apoptotic peptidase activating factor 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIN1 bridging integrator 1
BMP15 bone morphogenetic protein 15
CAPRIN2 caprin family member 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAST calpastatin
CC2D1A coiled-coil and C2 domain containing 1A
CD59 CD59 molecule, complement regulatory protein
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP131 centrosomal protein 131kDa
CLDN11 claudin 11
CLEC2B C-type lectin domain family 2, member B
CPM carboxypeptidase M
CREB3 cAMP responsive element binding protein 3
CRMP1 collapsin response mediator protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHDDS dehydrodolichyl diphosphate synthase
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNASE1L1 deoxyribonuclease I-like 1
DOCK4 dedicator of cytokinesis 4
DST dystonin
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECI2 enoyl-CoA delta isomerase 2
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FIG4 FIG4 phosphoinositide 5-phosphatase
GLTSCR1 glioma tumor suppressor candidate region gene 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2C integral membrane protein 2C
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KHK ketohexokinase (fructokinase)
KIF5C kinesin family member 5C
KRT32 keratin 32, type I
LBP lipopolysaccharide binding protein
LHFP lipoma HMGIC fusion partner
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MINPP1 multiple inositol-polyphosphate phosphatase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL1 myelin protein zero-like 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
PCNXL2 pecanex-like 2 (Drosophila)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PFN2 profilin 2
PLS1 plastin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RECQL4 RecQ protein-like 4
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHOC ras homolog family member C
SCML1 sex comb on midleg-like 1 (Drosophila)
SFTPB surfactant protein B
SHARPIN SHANK-associated RH domain interactor
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SUGP1 SURP and G patch domain containing 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TBC1D22A TBC1 domain family, member 22A
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TPD52L1 tumor protein D52-like 1
TRIM62 tripartite motif containing 62
TSPAN13 tetraspanin 13
TTC26 tetratricopeptide repeat domain 26
TUFT1 tuftelin 1
WDR19 WD repeat domain 19
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF45 zinc finger protein 45
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADI1 acireductone dioxygenase 1
ALDOC aldolase C, fructose-bisphosphate
ARAF A-Raf proto-oncogene, serine/threonine kinase
AVEN apoptosis, caspase activation inhibitor
BCL10 B-cell CLL/lymphoma 10
CARD9 caspase recruitment domain family, member 9
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CDC73 cell division cycle 73
CERS2 ceramide synthase 2
CHMP3 charged multivesicular body protein 3
CISH cytokine inducible SH2-containing protein
CTCF CCCTC-binding factor (zinc finger protein)
CTPS1 CTP synthase 1
DENND4B DENN/MADD domain containing 4B
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
ERCC2 excision repair cross-complementation group 2
EXOSC10 exosome component 10
FAM136A family with sequence similarity 136, member A
FAM216A family with sequence similarity 216, member A
FBXW4 F-box and WD repeat domain containing 4
FES FES proto-oncogene, tyrosine kinase
FGR FGR proto-oncogene, Src family tyrosine kinase
FMNL1 formin-like 1
GBAS glioblastoma amplified sequence
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GMPPB GDP-mannose pyrophosphorylase B
GPR183 G protein-coupled receptor 183
GRWD1 glutamate-rich WD repeat containing 1
GTPBP6 GTP binding protein 6 (putative)
HDAC4 histone deacetylase 4
IFRD2 interferon-related developmental regulator 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIF20B kinesin family member 20B
KLHL21 kelch-like family member 21
KPTN kaptin (actin binding protein)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LINC00341 long intergenic non-protein coding RNA 341
METTL21B methyltransferase like 21B
MGMT O-6-methylguanine-DNA methyltransferase
MORC3 MORC family CW-type zinc finger 3
MPDU1 mannose-P-dolichol utilization defect 1
MRPS34 mitochondrial ribosomal protein S34
MTERF3 mitochondrial transcription termination factor 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYBBP1A MYB binding protein (P160) 1a
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME6 NME/NM23 nucleoside diphosphate kinase 6
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUP43 nucleoporin 43kDa
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNT pericentrin
PCSK7 proprotein convertase subtilisin/kexin type 7
PNRC1 proline-rich nuclear receptor coactivator 1
POGLUT1 protein O-glucosyltransferase 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PRMT3 protein arginine methyltransferase 3
PRTN3 proteinase 3
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS7 pseudouridylate synthase 7 (putative)
RNH1 ribonuclease/angiogenin inhibitor 1
RPE ribulose-5-phosphate-3-epimerase
RPIA ribose 5-phosphate isomerase A
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS14P3 ribosomal protein S14 pseudogene 3
RSF1 remodeling and spacing factor 1
SACS sacsin molecular chaperone
SDF4 stromal cell derived factor 4
SEH1L SEH1-like (S. cerevisiae)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A38 solute carrier family 25, member 38
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMNDC1 survival motor neuron domain containing 1
SNHG3 small nucleolar RNA host gene 3
SNUPN snurportin 1
SPIN1 spindlin 1
TIPIN TIMELESS interacting protein
TRAPPC12 trafficking protein particle complex 12
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
UCK2 uridine-cytidine kinase 2
UNKL unkempt family zinc finger-like
WBSCR16 Williams-Beuren syndrome chromosome region 16
XPOT exportin, tRNA
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZCCHC10 zinc finger, CCHC domain containing 10