trichostatin A-2450 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the trichostatin A-2450 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACVR1B activin A receptor, type IB
ADGRL2 adhesion G protein-coupled receptor L2
AFF1 AF4/FMR2 family, member 1
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
B9D1 B9 protein domain 1
BCL2 B-cell CLL/lymphoma 2
BEGAIN brain-enriched guanylate kinase-associated
BLVRA biliverdin reductase A
CCR2 chemokine (C-C motif) receptor 2
CD177 CD177 molecule
CD59 CD59 molecule, complement regulatory protein
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CPM carboxypeptidase M
CRAT carnitine O-acetyltransferase
CRMP1 collapsin response mediator protein 1
CXCL6 chemokine (C-X-C motif) ligand 6
DHRS9 dehydrogenase/reductase (SDR family) member 9
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EFNA4 ephrin-A4
EPAS1 endothelial PAS domain protein 1
EPS8L1 EPS8-like 1
ETV1 ets variant 1
FAM118A family with sequence similarity 118, member A
FAM153A family with sequence similarity 153, member A
FCMR Fc fragment of IgM receptor
FOXO1 forkhead box O1
GK glycerol kinase
GM2A GM2 ganglioside activator
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNS glucosamine (N-acetyl)-6-sulfatase
GPR65 G protein-coupled receptor 65
GYPB glycophorin B (MNS blood group)
HMGN5 high mobility group nucleosome binding domain 5
HOXA1 homeobox A1
HRH4 histamine receptor H4
IL36A interleukin 36, alpha
IQCK IQ motif containing K
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JAG1 jagged 1
KIAA0319L KIAA0319-like
KIAA0513 KIAA0513
LEF1 lymphoid enhancer-binding factor 1
LMF1 lipase maturation factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAX MYC associated factor X
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MNX1 motor neuron and pancreas homeobox 1
MPZL1 myelin protein zero-like 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NCAM1 neural cell adhesion molecule 1
NDRG3 NDRG family member 3
NOTCH2 notch 2
OSBPL10 oxysterol binding protein-like 10
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PFKM phosphofructokinase, muscle
PFN2 profilin 2
PLCL1 phospholipase C-like 1
PLS1 plastin 1
POU4F1 POU class 4 homeobox 1
PRAMEF11 PRAME family member 11
PTK2B protein tyrosine kinase 2 beta
RAB26 RAB26, member RAS oncogene family
RASAL2 RAS protein activator like 2
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBPMS RNA binding protein with multiple splicing
RNF126P1 ring finger protein 126 pseudogene 1
RNF6 ring finger protein (C3H2C3 type) 6
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SCRN3 secernin 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SP110 SP110 nuclear body protein
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STON1 stonin 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPMT thiopurine S-methyltransferase
TUBB2A tubulin, beta 2A class IIa
ZC2HC1A zinc finger, C2HC-type containing 1A
ZER1 zyg-11 related, cell cycle regulator
ZNF235 zinc finger protein 235
ZNF280B zinc finger protein 280B
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACVR2A activin A receptor, type IIA
ACYP2 acylphosphatase 2, muscle type
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AXIN1 axin 1
BEST1 bestrophin 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BTBD18 BTB (POZ) domain containing 18
C16ORF59 chromosome 16 open reading frame 59
C1ORF56 chromosome 1 open reading frame 56
CCRL2 chemokine (C-C motif) receptor-like 2
CD79A CD79a molecule, immunoglobulin-associated alpha
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CEP170B centrosomal protein 170B
CES3 carboxylesterase 3
CHML choroideremia-like (Rab escort protein 2)
CLCN5 chloride channel, voltage-sensitive 5
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNPY4 canopy FGF signaling regulator 4
CTSO cathepsin O
DCAF13 DDB1 and CUL4 associated factor 13
DOK3 docking protein 3
DVL1 dishevelled segment polarity protein 1
E4F1 E4F transcription factor 1
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO46 F-box protein 46
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGL1 fibrinogen-like 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GMIP GEM interacting protein
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR27 G protein-coupled receptor 27
GPX2 glutathione peroxidase 2
GRIP2 glutamate receptor interacting protein 2
GTPBP6 GTP binding protein 6 (putative)
HAMP hepcidin antimicrobial peptide
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC8 homeobox C8
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
IFI6 interferon, alpha-inducible protein 6
IL1R2 interleukin 1 receptor, type II
IL3RA interleukin 3 receptor, alpha (low affinity)
KLHL28 kelch-like family member 28
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIMD2 LIM domain containing 2
LINS lines homolog (Drosophila)
LOC257152 uncharacterized LOC257152
MRAS muscle RAS oncogene homolog
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEUROD4 neuronal differentiation 4
NFS1 NFS1 cysteine desulfurase
NINJ2 ninjurin 2
NIPAL2 NIPA-like domain containing 2
NOL6 nucleolar protein 6 (RNA-associated)
NOTCH4 notch 4
NPFFR1 neuropeptide FF receptor 1
NXPH4 neurexophilin 4
OVGP1 oviductal glycoprotein 1, 120kDa
OXCT2 3-oxoacid CoA transferase 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PNOC prepronociceptin
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCAN3 RCAN family member 3
RNF122 ring finger protein 122
SCGB2A2 secretoglobin, family 2A, member 2
SH2D4A SH2 domain containing 4A
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPAG4 sperm associated antigen 4
SPATA2L spermatogenesis associated 2-like
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX1A syntaxin 1A (brain)
TERT telomerase reverse transcriptase
TET3 tet methylcytosine dioxygenase 3
TIGD6 tigger transposable element derived 6
TMEM206 transmembrane protein 206
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSPAN2 tetraspanin 2
TTLL1 tubulin tyrosine ligase-like family member 1
UPK3A uroplakin 3A
USP36 ubiquitin specific peptidase 36
VEGFC vascular endothelial growth factor C
VWA1 von Willebrand factor A domain containing 1
ZNF137P zinc finger protein 137, pseudogene
ZNF177 zinc finger protein 177
ZNF480 zinc finger protein 480
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZNF804A zinc finger protein 804A