trichostatin A-331 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trichostatin A-331 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AQP3 aquaporin 3 (Gill blood group)
ARMCX2 armadillo repeat containing, X-linked 2
BAIAP3 BAI1-associated protein 3
C7ORF43 chromosome 7 open reading frame 43
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKA choline kinase alpha
CHMP1B charged multivesicular body protein 1B
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLGN calmegin
CORO1A coronin, actin binding protein, 1A
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DEGS1 delta(4)-desaturase, sphingolipid 1
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK4 docking protein 4
DUS2 dihydrouridine synthase 2
EFNB3 ephrin-B3
EHD1 EH-domain containing 1
ENG endoglin
EPOR erythropoietin receptor
FAM110B family with sequence similarity 110, member B
FAM214B family with sequence similarity 214, member B
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GCHFR GTP cyclohydrolase I feedback regulator
GLG1 golgi glycoprotein 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRK5 G protein-coupled receptor kinase 5
GSK3A glycogen synthase kinase 3 alpha
H1F0 H1 histone family, member 0
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA1033 KIAA1033
KIF5C kinesin family member 5C
KLHL25 kelch-like family member 25
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00339 long intergenic non-protein coding RNA 339
LPPR2 lipid phosphate phosphatase-related protein type 2
LUZP1 leucine zipper protein 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MCOLN1 mucolipin 1
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
NARF nuclear prelamin A recognition factor
NES nestin
NME5 NME/NM23 family member 5
NPAT nuclear protein, ataxia-telangiectasia locus
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PPARD peroxisome proliferator-activated receptor delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTRF polymerase I and transcript release factor
RAB28 RAB28, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RNFT1 ring finger protein, transmembrane 1
RNFT2 ring finger protein, transmembrane 2
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERHL2 serine hydrolase-like 2
SERINC5 serine incorporator 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFXN3 sideroflexin 3
SH3GL3 SH3-domain GRB2-like 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNAI1 snail family zinc finger 1
STK17A serine/threonine kinase 17a
TGM3 transglutaminase 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM23 tripartite motif containing 23
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
VCL vinculin
VIPR1 vasoactive intestinal peptide receptor 1
VRK3 vaccinia related kinase 3
WDR47 WD repeat domain 47
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALX1 ALX homeobox 1
AMT aminomethyltransferase
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP9A ATPase, class II, type 9A
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTBD2 BTB (POZ) domain containing 2
C10ORF2 chromosome 10 open reading frame 2
CALHM2 calcium homeostasis modulator 2
CAPN15 calpain 15
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CCNK cyclin K
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFNA1 ephrin-A1
ELP3 elongator acetyltransferase complex subunit 3
ERO1L ERO1-like (S. cerevisiae)
ESRP2 epithelial splicing regulatory protein 2
FAM110D family with sequence similarity 110, member D
FJX1 four jointed box 1 (Drosophila)
FLJ11710 uncharacterized protein FLJ11710
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUZ fuzzy planar cell polarity protein
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATA3 GATA binding protein 3
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GPRC5C G protein-coupled receptor, class C, group 5, member C
HBD hemoglobin, delta
HIRIP3 HIRA interacting protein 3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRS1 insulin receptor substrate 1
IRS4 insulin receptor substrate 4
IRX4 iroquois homeobox 4
IRX5 iroquois homeobox 5
KEAP1 kelch-like ECH-associated protein 1
LCN2 lipocalin 2
LIAS lipoic acid synthetase
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MEPE matrix extracellular phosphoglycoprotein
METTL8 methyltransferase like 8
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NCKAP1L NCK-associated protein 1-like
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PHOX2A paired-like homeobox 2a
POGK pogo transposable element with KRAB domain
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPCDC phosphopantothenoylcysteine decarboxylase
PQLC3 PQ loop repeat containing 3
PRCC papillary renal cell carcinoma (translocation-associated)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SREK1 splicing regulatory glutamine/lysine-rich protein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAG1 stromal antigen 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMED1 transmembrane emp24 protein transport domain containing 1
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIB3 tribbles pseudokinase 3
TRIM8 tripartite motif containing 8
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
UBQLN4 ubiquilin 4
UBTF upstream binding transcription factor, RNA polymerase I
URGCP upregulator of cell proliferation
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBED5 zinc finger, BED-type containing 5
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF276 zinc finger protein 276
Funding