trichostatin A-4072 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4072 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AGTR1 angiotensin II receptor, type 1
AIM1L absent in melanoma 1-like
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C14ORF79 chromosome 14 open reading frame 79
CA5B carbonic anhydrase VB, mitochondrial
CCL20 chemokine (C-C motif) ligand 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COL21A1 collagen, type XXI, alpha 1
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DENND3 DENN/MADD domain containing 3
DLX5 distal-less homeobox 5
DPF1 D4, zinc and double PHD fingers family 1
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
EFNA3 ephrin-A3
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESRRG estrogen-related receptor gamma
FABP4 fatty acid binding protein 4, adipocyte
FOS FBJ murine osteosarcoma viral oncogene homolog
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXA1 homeobox A1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LINC00312 long intergenic non-protein coding RNA 312
LINC00341 long intergenic non-protein coding RNA 341
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
MAK male germ cell-associated kinase
MAN1C1 mannosidase, alpha, class 1C, member 1
MAST3 microtubule associated serine/threonine kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLSCR4 phospholipid scramblase 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RNF24 ring finger protein 24
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORBS1 sorbin and SH3 domain containing 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
STC1 stanniocalcin 1
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIK TRAF2 and NCK interacting kinase
TRIM36 tripartite motif containing 36
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
USP2 ubiquitin specific peptidase 2
USP53 ubiquitin specific peptidase 53
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADGRG6 adhesion G protein-coupled receptor G6
ADNP activity-dependent neuroprotector homeobox
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
APOL6 apolipoprotein L, 6
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARSJ arylsulfatase family, member J
ATF1 activating transcription factor 1
BCAR3 breast cancer anti-estrogen resistance 3
BOLA1 bolA family member 1
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CLCF1 cardiotrophin-like cytokine factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DEPDC1 DEP domain containing 1
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBX2 gastrulation brain homeobox 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
HOXA4 homeobox A4
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
METTL4 methyltransferase like 4
MSL1 male-specific lethal 1 homolog (Drosophila)
MTPAP mitochondrial poly(A) polymerase
NDP Norrie disease (pseudoglioma)
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NOD1 nucleotide-binding oligomerization domain containing 1
NRIP1 nuclear receptor interacting protein 1
NRSN2 neurensin 2
NUP62 nucleoporin 62kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARP16 poly (ADP-ribose) polymerase family, member 16
PARP2 poly (ADP-ribose) polymerase 2
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PPAN peter pan homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
PTK6 protein tyrosine kinase 6
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCAF8 SR-related CTD-associated factor 8
SETD1B SET domain containing 1B
SH2D4A SH2 domain containing 4A
SIM2 single-minded family bHLH transcription factor 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SRSF4 serine/arginine-rich splicing factor 4
STBD1 starch binding domain 1
TBX3 T-box 3
TENM4 teneurin transmembrane protein 4
THAP1 THAP domain containing, apoptosis associated protein 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM254 transmembrane protein 254
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM13 tripartite motif containing 13
TRIM16 tripartite motif containing 16
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBGCP3 tubulin, gamma complex associated protein 3
UBTF upstream binding transcription factor, RNA polymerase I
UBXN8 UBX domain protein 8
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZNF16 zinc finger protein 16
ZNF33B zinc finger protein 33B
ZNF562 zinc finger protein 562
ZNF692 zinc finger protein 692
ZNF76 zinc finger protein 76
ZNHIT2 zinc finger, HIT-type containing 2
Funding