trichostatin A-448 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the trichostatin A-448 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ADAP2 ArfGAP with dual PH domains 2
AGFG2 ArfGAP with FG repeats 2
AHCYL2 adenosylhomocysteinase-like 2
ARHGAP26 Rho GTPase activating protein 26
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
BAIAP2 BAI1-associated protein 2
BDNF brain-derived neurotrophic factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CA12 carbonic anhydrase XII
CAV3 caveolin 3
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFAP69 cilia and flagella associated protein 69
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTIF CBP80/20-dependent translation initiation factor
CYLD cylindromatosis (turban tumor syndrome)
DUSP10 dual specificity phosphatase 10
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F6 E2F transcription factor 6
ELMO2 engulfment and cell motility 2
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GALR3 galanin receptor 3
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLS glutaminase
GSK3A glycogen synthase kinase 3 alpha
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HAPLN2 hyaluronan and proteoglycan link protein 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL1RAP interleukin 1 receptor accessory protein
INSIG2 insulin induced gene 2
JUNB jun B proto-oncogene
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KIF5C kinesin family member 5C
KLF15 Kruppel-like factor 15
KLK12 kallikrein-related peptidase 12
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP6 low density lipoprotein receptor-related protein 6
LRRC1 leucine rich repeat containing 1
LUZP1 leucine zipper protein 1
MAST2 microtubule associated serine/threonine kinase 2
MEGF9 multiple EGF-like-domains 9
MFSD12 major facilitator superfamily domain containing 12
MNAT1 MNAT CDK-activating kinase assembly factor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NIPAL3 NIPA-like domain containing 3
NXN nucleoredoxin
NXPH4 neurexophilin 4
PAIP2B poly(A) binding protein interacting protein 2B
PAX3 paired box 3
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDLIM5 PDZ and LIM domain 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRB1 proline-rich protein BstNI subfamily 1
PRKCD protein kinase C, delta
PRSS8 protease, serine, 8
PSIP1 PC4 and SFRS1 interacting protein 1
RAB8B RAB8B, member RAS oncogene family
RNF24 ring finger protein 24
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RTN2 reticulon 2
SEPW1 selenoprotein W, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC38A7 solute carrier family 38, member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SMOX spermine oxidase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNPH syntaphilin
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STC1 stanniocalcin 1
STK4 serine/threonine kinase 4
SYTL2 synaptotagmin-like 2
TMEM47 transmembrane protein 47
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TRIM62 tripartite motif containing 62
TSPAN32 tetraspanin 32
TUFT1 tuftelin 1
USP20 ubiquitin specific peptidase 20
WDR91 WD repeat domain 91
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADNP activity-dependent neuroprotector homeobox
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARSJ arylsulfatase family, member J
ATF1 activating transcription factor 1
ATF7IP2 activating transcription factor 7 interacting protein 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BANP BTG3 associated nuclear protein
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
C19ORF57 chromosome 19 open reading frame 57
C1ORF109 chromosome 1 open reading frame 109
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCF1 cardiotrophin-like cytokine factor 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
COMMD8 COMM domain containing 8
CTCF CCCTC-binding factor (zinc finger protein)
EMC9 ER membrane protein complex subunit 9
ERMP1 endoplasmic reticulum metallopeptidase 1
ESM1 endothelial cell-specific molecule 1
ETV4 ets variant 4
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FOXC1 forkhead box C1
FST follistatin
GSTZ1 glutathione S-transferase zeta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL15RA interleukin 15 receptor, alpha
INHBB inhibin, beta B
IRF9 interferon regulatory factor 9
ITPKB inositol-trisphosphate 3-kinase B
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
KIFC1 kinesin family member C1
LIF leukemia inhibitory factor
LINC00339 long intergenic non-protein coding RNA 339
LMNB1 lamin B1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRIF1 ligand dependent nuclear receptor interacting factor 1
MEPCE methylphosphate capping enzyme
METTL2B methyltransferase like 2B
MTIF2 mitochondrial translational initiation factor 2
MUC2 mucin 2, oligomeric mucus/gel-forming
NDC80 NDC80 kinetochore complex component
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PFAS phosphoribosylformylglycinamidine synthase
RBM22 RNA binding motif protein 22
RBM39 RNA binding motif protein 39
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
RIPPLY3 ripply transcriptional repressor 3
RNF220 ring finger protein 220
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCAF8 SR-related CTD-associated factor 8
SLC17A4 solute carrier family 17, member 4
SMYD5 SMYD family member 5
SPOP speckle-type POZ protein
SRSF4 serine/arginine-rich splicing factor 4
STBD1 starch binding domain 1
STXBP3 syntaxin binding protein 3
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYT2 synaptotagmin II
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THUMPD1 THUMP domain containing 1
TMEM168 transmembrane protein 168
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM5 tripartite motif containing 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSSC4 tumor suppressing subtransferable candidate 4
TTC4 tetratricopeptide repeat domain 4
URGCP upregulator of cell proliferation
USF2 upstream transcription factor 2, c-fos interacting
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
WDR13 WD repeat domain 13
WDR41 WD repeat domain 41
WNT7A wingless-type MMTV integration site family, member 7A
ZBED1 zinc finger, BED-type containing 1
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF329 zinc finger protein 329
ZNF652 zinc finger protein 652