tridihexethyl-3526 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tridihexethyl-3526 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACACB acetyl-CoA carboxylase beta
ADAM20 ADAM metallopeptidase domain 20
ADGRG1 adhesion G protein-coupled receptor G1
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGAP19 Rho GTPase activating protein 19
ARHGAP33 Rho GTPase activating protein 33
ARHGAP4 Rho GTPase activating protein 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAIAP2 BAI1-associated protein 2
BTK Bruton agammaglobulinemia tyrosine kinase
C17ORF53 chromosome 17 open reading frame 53
C1ORF54 chromosome 1 open reading frame 54
C1ORF68 chromosome 1 open reading frame 68
CCDC28B coiled-coil domain containing 28B
CD83 CD83 molecule
CDK18 cyclin-dependent kinase 18
CDON cell adhesion associated, oncogene regulated
CDR2L cerebellar degeneration-related protein 2-like
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CUL7 cullin 7
CUL9 cullin 9
DAZAP1 DAZ associated protein 1
DBF4B DBF4 zinc finger B
DMP1 dentin matrix acidic phosphoprotein 1
DSCAM Down syndrome cell adhesion molecule
DUSP6 dual specificity phosphatase 6
ETNK2 ethanolamine kinase 2
FAM65A family with sequence similarity 65, member A
FKBP10 FK506 binding protein 10, 65 kDa
FLJ22184
FXR2 fragile X mental retardation, autosomal homolog 2
FZD10 frizzled class receptor 10
GLIPR1 GLI pathogenesis-related 1
GPR137 G protein-coupled receptor 137
HAP1 huntingtin-associated protein 1
HCFC1 host cell factor C1
HPX hemopexin
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKZF4 IKAROS family zinc finger 4 (Eos)
IPO8 importin 8
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNIP1 Kv channel interacting protein 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF1C kinesin family member 1C
KMT2A lysine (K)-specific methyltransferase 2A
KRT9 keratin 9, type I
LAPTM5 lysosomal protein transmembrane 5
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K5 mitogen-activated protein kinase kinase 5
MCAM melanoma cell adhesion molecule
MDM4 MDM4, p53 regulator
MLANA melan-A
MLNR motilin receptor
MUC1 mucin 1, cell surface associated
NCDN neurochondrin
NDOR1 NADPH dependent diflavin oxidoreductase 1
NF2 neurofibromin 2 (merlin)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH3 notch 3
NPM3 nucleophosmin/nucleoplasmin 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PBX2 pre-B-cell leukemia homeobox 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAUR plasminogen activator, urokinase receptor
PLXNC1 plexin C1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTCRA pre T-cell antigen receptor alpha
PXN paxillin
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBDD3 rhomboid domain containing 3
RIN3 Ras and Rab interactor 3
RNF208 ring finger protein 208
SGSH N-sulfoglucosamine sulfohydrolase
SLC25A44 solute carrier family 25, member 44
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
TBKBP1 TBK1 binding protein 1
THEM6 thioesterase superfamily member 6
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM63A transmembrane protein 63A
TMPRSS4 transmembrane protease, serine 4
TRIM3 tripartite motif containing 3
TROVE2 TROVE domain family, member 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF304 zinc finger protein 304
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADAM15 ADAM metallopeptidase domain 15
AES amino-terminal enhancer of split
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BAG4 BCL2-associated athanogene 4
BAX BCL2-associated X protein
C10ORF95 chromosome 10 open reading frame 95
C17ORF80 chromosome 17 open reading frame 80
C4ORF29 chromosome 4 open reading frame 29
CCDC186 coiled-coil domain containing 186
CENPJ centromere protein J
CXCR2 chemokine (C-X-C motif) receptor 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A2 eukaryotic translation initiation factor 5A2
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
FAM46C family with sequence similarity 46, member C
FAN1 FANCD2/FANCI-associated nuclease 1
FBXO31 F-box protein 31
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
FUZ fuzzy planar cell polarity protein
GALK1 galactokinase 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDAP1 ganglioside induced differentiation associated protein 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLUD2 glutamate dehydrogenase 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GSTM2 glutathione S-transferase mu 2 (muscle)
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2BO histone cluster 1, H2bo
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
IFT22 intraflagellar transport 22
INPP1 inositol polyphosphate-1-phosphatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCTD20 potassium channel tetramerization domain containing 20
LHX6 LIM homeobox 6
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LY6D lymphocyte antigen 6 complex, locus D
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MBTD1 mbt domain containing 1
MED18 mediator complex subunit 18
METTL16 methyltransferase like 16
MFAP2 microfibrillar-associated protein 2
MICALL2 MICAL-like 2
MITF microphthalmia-associated transcription factor
MPHOSPH8 M-phase phosphoprotein 8
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY5R neuropeptide Y receptor Y5
PARPBP PARP1 binding protein
PDIA3 protein disulfide isomerase family A, member 3
PLA2G3 phospholipase A2, group III
PRPF39 pre-mRNA processing factor 39
PSENEN presenilin enhancer gamma secretase subunit
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RANGRF RAN guanine nucleotide release factor
RUSC2 RUN and SH3 domain containing 2
SCAI suppressor of cancer cell invasion
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC16A6 solute carrier family 16, member 6
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOWAHC sosondowah ankyrin repeat domain family member C
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STX1A syntaxin 1A (brain)
SYTL2 synaptotagmin-like 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPRL TOR signaling pathway regulator
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM25 tripartite motif containing 25
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VASH2 vasohibin 2
WDR4 WD repeat domain 4
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZMAT5 zinc finger, matrin-type 5
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF586 zinc finger protein 586
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675
ZNF91 zinc finger protein 91