trifluoperazine-1224 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trifluoperazine-1224 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
AKAP7 A kinase (PRKA) anchor protein 7
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ARHGAP24 Rho GTPase activating protein 24
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCAM basal cell adhesion molecule (Lutheran blood group)
C5ORF45 chromosome 5 open reading frame 45
CA5B carbonic anhydrase VB, mitochondrial
CDC14A cell division cycle 14A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN1 claudin 1
CLEC2B C-type lectin domain family 2, member B
CNR2 cannabinoid receptor 2 (macrophage)
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ECE1 endothelin converting enzyme 1
EFNB3 ephrin-B3
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM174B family with sequence similarity 174, member B
FLJ10038 uncharacterized protein FLJ10038
FLT4 fms-related tyrosine kinase 4
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GK glycerol kinase
GRIP2 glutamate receptor interacting protein 2
HDAC7 histone deacetylase 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1RN interleukin 1 receptor antagonist
IL33R interleukin 33 receptor
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
INO80B INO80 complex subunit B
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF3 Kruppel-like factor 3 (basic)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LRRC1 leucine rich repeat containing 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP2K3 mitogen-activated protein kinase kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MON1B MON1 secretory trafficking family member B
MST1 macrophage stimulating 1
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOZ3 myozenin 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODF2 outer dense fiber of sperm tails 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PHF3 PHD finger protein 3
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLH polymerase (DNA directed), eta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRB1 proline-rich protein BstNI subfamily 1
PTAFR platelet-activating factor receptor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RRAD Ras-related associated with diabetes
RUNX1 runt-related transcription factor 1
RXRA retinoid X receptor, alpha
RYR2 ryanodine receptor 2 (cardiac)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SH2D2A SH2 domain containing 2A
SIRPA signal-regulatory protein alpha
SLC22A14 solute carrier family 22, member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TBX10 T-box 10
THRB thyroid hormone receptor, beta
TM4SF1 transmembrane 4 L six family member 1
TMEM209 transmembrane protein 209
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSKS testis-specific serine kinase substrate
TSNAXIP1 translin-associated factor X interacting protein 1
USB1 U6 snRNA biogenesis 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
AEN apoptosis enhancing nuclease
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALG3 ALG3, alpha-1,3- mannosyltransferase
ANKRD36 ankyrin repeat domain 36
ARHGAP11A Rho GTPase activating protein 11A
ARSJ arylsulfatase family, member J
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRIX1 BRX1, biogenesis of ribosomes
C10ORF88 chromosome 10 open reading frame 88
C11ORF73 chromosome 11 open reading frame 73
CBX7 chromobox homolog 7
CCNA2 cyclin A2
CD3EAP CD3e molecule, epsilon associated protein
CENPT centromere protein T
CHML choroideremia-like (Rab escort protein 2)
CHPF chondroitin polymerizing factor
CHST10 carbohydrate sulfotransferase 10
CTSO cathepsin O
CUEDC1 CUE domain containing 1
CUTC cutC copper transporter
DBF4 DBF4 zinc finger
DENND4B DENN/MADD domain containing 4B
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
E2F8 E2F transcription factor 8
EDN1 endothelin 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FPGT fucose-1-phosphate guanylyltransferase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GPATCH3 G patch domain containing 3
GRPR gastrin-releasing peptide receptor
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HDAC4 histone deacetylase 4
HIST1H1D histone cluster 1, H1d
HOXC13 homeobox C13
HPS5 Hermansky-Pudlak syndrome 5
HSPA4L heat shock 70kDa protein 4-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL33 interleukin 33
IRS1 insulin receptor substrate 1
KATNBL1 katanin p80 subunit B-like 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD15 potassium channel tetramerization domain containing 15
KIAA0753 KIAA0753
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
MAGEH1 melanoma antigen family H1
MANBA mannosidase, beta A, lysosomal
MANSC1 MANSC domain containing 1
MCM3 minichromosome maintenance complex component 3
MCMBP minichromosome maintenance complex binding protein
MFSD11 major facilitator superfamily domain containing 11
MNS1 meiosis-specific nuclear structural 1
MYLIP myosin regulatory light chain interacting protein
MYLK myosin light chain kinase
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAT10 N-acetyltransferase 10 (GCN5-related)
NDRG4 NDRG family member 4
NFS1 NFS1 cysteine desulfurase
NOL12 nucleolar protein 12
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
ORC1 origin recognition complex, subunit 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDZD2 PDZ domain containing 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPT2 palmitoyl-protein thioesterase 2
PRMT7 protein arginine methyltransferase 7
PTK6 protein tyrosine kinase 6
PTK7 protein tyrosine kinase 7 (inactive)
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC22A18 solute carrier family 22, member 18
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST5 suppression of tumorigenicity 5
TESK1 testis-specific kinase 1
TMEM120B transmembrane protein 120B
TMPO thymopoietin
TRIM9 tripartite motif containing 9
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
WDR18 WD repeat domain 18
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF16 zinc finger protein 16
ZNF286A zinc finger protein 286A
ZNF350 zinc finger protein 350
ZNF611 zinc finger protein 611
ZNF675 zinc finger protein 675
ZNF84 zinc finger protein 84