trifluoperazine-1649 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trifluoperazine-1649 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALS2CL ALS2 C-terminal like
AQP3 aquaporin 3 (Gill blood group)
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARL2BP ADP-ribosylation factor-like 2 binding protein
ARTN artemin
ATF3 activating transcription factor 3
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BIRC3 baculoviral IAP repeat containing 3
C14ORF93 chromosome 14 open reading frame 93
C16ORF45 chromosome 16 open reading frame 45
C2ORF27A chromosome 2 open reading frame 27A
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CEP68 centrosomal protein 68kDa
CFHR4 complement factor H-related 4
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNB31 deafness, autosomal recessive 31
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGFL7 EGF-like-domain, multiple 7
EGR1 early growth response 1
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM186A family with sequence similarity 186, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FSCN1 fascin actin-bundling protein 1
GPC1 glypican 1
GRB10 growth factor receptor-bound protein 10
GRIK5 glutamate receptor, ionotropic, kainate 5
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
ING1 inhibitor of growth family, member 1
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLHL28 kelch-like family member 28
LAMP1 lysosomal-associated membrane protein 1
LMNA lamin A/C
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MST1R macrophage stimulating 1 receptor
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKLR pyruvate kinase, liver and RBC
PLA2G3 phospholipase A2, group III
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP5C protein phosphatase 5, catalytic subunit
PRLR prolactin receptor
PTGES prostaglandin E synthase
PTRF polymerase I and transcript release factor
RYR2 ryanodine receptor 2 (cardiac)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24A SEC24 family member A
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPINK4 serine peptidase inhibitor, Kazal type 4
STRN3 striatin, calmodulin binding protein 3
SVIL supervillin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRAK1 trafficking protein, kinesin binding 1
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
ULBP2 UL16 binding protein 2
VAC14 Vac14 homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
ZNF141 zinc finger protein 141

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACIN1 apoptotic chromatin condensation inducer 1
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADCY6 adenylate cyclase 6
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ATAD3A ATPase family, AAA domain containing 3A
BCOR BCL6 corepressor
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF80 chromosome 11 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C2CD2 C2 calcium-dependent domain containing 2
C5ORF45 chromosome 5 open reading frame 45
CENPC centromere protein C
CLASP1 cytoplasmic linker associated protein 1
CLSPN claspin
COG4 component of oligomeric golgi complex 4
COPS7B COP9 signalosome subunit 7B
CPTP ceramide-1-phosphate transfer protein
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
E2F8 E2F transcription factor 8
EFHD2 EF-hand domain family, member D2
ELOVL4 ELOVL fatty acid elongase 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHA4 EPH receptor A4
EPN3 epsin 3
ERCC8 excision repair cross-complementation group 8
FASTKD5 FAST kinase domains 5
FBXL6 F-box and leucine-rich repeat protein 6
FLJ22184
GBP2 guanylate binding protein 2, interferon-inducible
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GHR growth hormone receptor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMIP GEM interacting protein
GTF2I general transcription factor IIi
GYS1 glycogen synthase 1 (muscle)
HMHA1 histocompatibility (minor) HA-1
HOXC13 homeobox C13
HTRA1 HtrA serine peptidase 1
ITPKB inositol-trisphosphate 3-kinase B
JADE3 jade family PHD finger 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLHL21 kelch-like family member 21
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG1 ligase I, DNA, ATP-dependent
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1S microtubule-associated protein 1S
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFE2L3 nuclear factor, erythroid 2-like 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUP62CL nucleoporin 62kDa C-terminal like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OTUD3 OTU deubiquitinase 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR3 progestin and adipoQ receptor family member III
PCDHB3 protocadherin beta 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP6R3 protein phosphatase 6, regulatory subunit 3
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRU protein tyrosine phosphatase, receptor type, U
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RFTN1 raftlin, lipid raft linker 1
RIBC2 RIB43A domain with coiled-coils 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC12A9 solute carrier family 12, member 9
SLC16A6 solute carrier family 16, member 6
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMA4 glucuronidase, beta pseudogene
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMYD5 SMYD family member 5
SUSD4 sushi domain containing 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFB3 transforming growth factor, beta 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM180 transmembrane protein 180
TMEM184B transmembrane protein 184B
TPCN1 two pore segment channel 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UBTF upstream binding transcription factor, RNA polymerase I
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VASH1 vasohibin 1
ZBED1 zinc finger, BED-type containing 1
ZFAND3 zinc finger, AN1-type domain 3
ZNF768 zinc finger protein 768
ZNF787 zinc finger protein 787